BioCMOS technology and its application to portable biosensor instruments

生物CMOS技术是将生物分子集成在半导体集成电路上的技术，包括生物分子电学检测新方法、模拟CMOS集成电路新设计、组装新工艺等。目标是便携式基于基因的即时检测（POCT）系统。建立了氧化还原电位检测方法，信号稳定性提高了两个数量级。制作了氧化还原电位传感器阵列，并对人体血液中葡萄糖浓度进行了准确测定和DNA测序。基于电位、电流和阻抗检测的多模态电化学传感器阵列，使综合分析成为可能，并使生物传感器芯片标准化成为可能。

BioCMOS technology, integration of biomolecules on semiconductor integrated circuit, has been developed, including new electrical detection methods of biomolecules, new design of analog CMOS integrated circuit, and new assembling technology . The target is portable gene-based point-of-care testing (POCT) system. Redox potential detection method has been developed and the signal stability was drastically improved by two orders. Fabricating a redox potential sensor array, accurately determination ofglucose levels in human blood and DNA sequencing were demonstrated. A multimodal electrochemical sensor arrays based on the detection of electric potential, current, and impedance, which enables synthetic analysis and makes it possible to standardize biosensor chip, has been developed.