Integrated elucidation of metabolic pathway in the physiology and pathology

生理病理代谢途径的综合阐明

• 批准号: 20229008
• 负责人: KADOWAKI Takashi
• 金额: $ 145.43万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20229008/
• 关键词: アディポネクチン; インスリン; AdipoR; 糖代謝; 脂質代謝

An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contributed to generating scientific evidence that constitutes a basis for the development of anti妖iabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by elucidating the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.

对代谢调节及其破坏的综合理解对于阐明糖尿病和代谢综合征的病理生理以及为这些疾病发展治疗方式而言至关重要。在这方面，我们有助于产生科学证据，该证据构成了针对胰岛素和/或脂联素作用调节的抗Yambabetic疗法的发展，以及发现候选抗糖尿病化合物的发现，通过阐明在胰岛素和////或ADIPONCENT中涉及的机制，通过阐明涉及的机制。

项目成果

Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies.

• DOI: 10.1371/journal.pone.0042031
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yamada T;Hara K;Kadowaki T
• 通讯作者: Kadowaki T

Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle.

内皮细胞中的胰岛素信号受损会减少骨骼肌胰岛素诱导的葡萄糖摄取。

• 发表时间: 2011
• 期刊: Cell Metabolism 13
• 作者: Kubota T;Kubota N;Kumagai H;Yamaguchi S;Kozono H;Takahashi T;Inoue M;Itoh S;Takamoto I;Sasako T;Kumagai K;Kawai T;Hashimoto S;Kobayashi T;Sato M;Tokuyama K;Nishimura S;Tsunoda M;Ide T;Murakami K;Yamazaki T;Ezaki O;Kawamura K;Masuda
• 通讯作者: Masuda

2型糖尿病の体質とそれをふまえた治療戦略

2型糖尿病体质及其治疗策略

• 发表时间: 2009
• 作者: 宮澤陽夫;仲川清隆;指宿大悟;浅井明;及川眞一;張思予;門脇孝
• 通讯作者: 門脇孝

1st International Conference on Immuno Metabolism

第一届国际免疫代谢会议

• 发表时间: 2011
• 作者: M Akimoto;M Nakamura;A Sawada;N Mukumoto;N Ueki;S Kaneko;Y Matsuo;T Mizowaki;M Kokubo;M Hiraoka;Kotaro Kitagawa and Kumiko Tanaka-Ishii;門脇孝
• 通讯作者: 門脇孝

A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

• DOI: 10.1016/j.cmet.2010.09.015
• 发表时间: 2010-11-03
• 期刊: CELL METABOLISM
• 影响因子: 29
• 作者: Misu, Hirofumi;Takamura, Toshinari;Kaneko, Shuichi
• 通讯作者: Kaneko, Shuichi