Integrated elucidation of metabolic pathway in the physiology and pathology

生理病理代谢途径的综合阐明

• 批准号: 20229008
• 负责人: KADOWAKI Takashi
• 金额: $ 145.43万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20229008/
• 关键词: アディポネクチン; インスリン; AdipoR; 糖代謝; 脂質代謝

An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contributed to generating scientific evidence that constitutes a basis for the development of anti妖iabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by elucidating the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.

An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contribute to generating scientific evidence that constitutes a basis for the development of anti diabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by inducing the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.

项目成果

Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies.

• DOI: 10.1371/journal.pone.0042031
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yamada T;Hara K;Kadowaki T
• 通讯作者: Kadowaki T

Impact of IncreasedPPARgamma Activity in Adipocytes invivo on Adiposity, Insulin Sensitivityand the Effects of RosiglitazoneTreatment

体内脂肪细胞 PPARgamma 活性增加对肥胖、胰岛素敏感性和罗格列酮治疗效果的影响

• 发表时间: 2008
• 期刊: Endocr. J 55
• 作者: Takasawa K;Kubota N;Terauchi Y;Kadowaki T.
• 通讯作者: Kadowaki T.

Adiponectin and AdipoRl regulate PGCI and mitochondria by Ca^<2+> and AMPK/SIRTI.

脂联素和AdipoRI通过Ca 2 和AMPK/SIRTI调节PGCI和线粒体。

• 发表时间: 2010
• 期刊: Nature
• 影响因子: 64.8
• 作者: Iwabu M;Yamauchi T;Okada-lwabu M;Sato K;Nakagawa T;Funata M;Pamaguchi M;Namiki S;Nakayama R;Tabata M;Ogata H;.Kubota N;Takamoto I;Hayashi YK;Yamauchi N;Waki H;Fukayama M;Nishino I;Tokuyama K;Ueki K;Oike Y;Ishii S;Hirose K;Shimizu T,
• 通讯作者: Shimizu T,

2型糖尿病の体質とそれをふまえた治療戦略

2型糖尿病体质及其治疗策略

• 发表时间: 2009
• 作者: 宮澤陽夫;仲川清隆;指宿大悟;浅井明;及川眞一;張思予;門脇孝
• 通讯作者: 門脇孝

Epidemic of type 2 diabetes in Japan-Its causes and preventive strategies

日本2型糖尿病的流行-原因及预防策略

• 发表时间: 2009
• 作者: 柴田央;仲川清隆;宮澤陽夫;升島努;藤本公道;門脇孝
• 通讯作者: 門脇孝