Integrated elucidation of metabolic pathway in the physiology and pathology

An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contributed to generating scientific evidence that constitutes a basis for the development of anti妖iabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by elucidating the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.

An integrated understanding of metabolic regulation and its disruption is essential in elucidating the pathophysiology of diabetes and the metabolic syndrome as well as in developing therapeutic modalities for these conditions. In this connection, we contributed to generating scientific evidence that constitutes a basis for the development of anti妖iabetic therapies targeted at the regulation of insulin and/or adiponectin action as well as to the discovery of candidate anti-diabetic compounds, by elucidating the mechanisms involved in the inter-organ cross-walks in the regulation of insulin and/or adiponectin action.