Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies.
Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies.
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DOI：
10.1371/journal.pone.0042031
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kadowaki T
中科院分区：
文献类型：
--
作者：
Yamada T;Hara K;Kadowaki T
一些研究表明，腺病毒36（Ad 36）影响人类肥胖的风险。阐明Ad 36感染和肥胖之间的关系可能会导致更有效的方法来管理肥胖。本研究的目的是进行荟萃分析，以确认Ad 36感染对肥胖和代谢标志物的影响。我们检索了MEDLINE和科克伦图书馆1951年至2012年4月22日期间发表的相关文章（包括参考文献）。本荟萃分析仅纳入了原始观察性研究的英文报告。数据提取由两名审查员独立进行。使用随机效应模型计算加权平均差异（WMD）和合并比值比（OR）及其95%置信区间（95% CI）。在237项潜在相关研究中，10项横断面研究（n = 2，870）符合选择标准。 合并分析显示，Ad 36感染者与非感染者相比，BMI的WMD为3.19（95%CI 1.44-4.93; P<0.001）。仅限于成人研究的敏感性分析得出了相似的结果，为3.18（95% CI 0.78-5.57; P = 0.009）。 与Ad 36感染相关的肥胖风险增加也是显著的（OR：1.9; 95%CI：1.01-3.56; P = 0.047）。 总胆固醇（P = 0.83）、甘油三酯（P = 0.64）、高密度脂蛋白（P = 0.69）、血糖（P = 0.08）、腰围（P = 0.09）和收缩压（P = 0.25）无显著性差异。 Ad 36感染与肥胖和体重增加的风险相关，但与包括腰围在内的代谢指标异常无关。这表明Ad 36感染与皮下脂肪堆积的关系比内脏脂肪堆积的关系更密切。Ad 36与肥胖之间的关系应通过进一步的研究进行评估，包括精心设计的前瞻性研究，以更好地了解Ad 36是否在人类肥胖的病因学中发挥作用。
Several studies have shown that Adenovirus 36 (Ad36) influences the risk of obesity in humans. Clarifying the relationship between Ad36 infection and obesity could lead to more effective approaches for the management of obesity. The objective of this study was to conduct a meta-analysis to confirm the influence of Ad36 infection on obesity and metabolic markers. We searched MEDLINE and the Cochrane Library for pertinent articles (including their references) published between 1951 and April 22, 2012. Only English language reports of original observational studies were included in this meta-analysis. Data extraction was performed independently by two reviewers. Weighted mean differences (WMDs) and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using the random effects model. Of 237 potentially relevant studies, 10 cross-sectional studies (n = 2,870) conformed to the selection criteria. Pooled analysis showed that the WMD for BMI of Ad36 infection compared with non-infection was 3.19 (95% CI 1.44–4.93; P<0.001). Sensitivity analysis restricted to studies of adults yielded a similar result of 3.18 (95% CI 0.78–5.57; P = 0.009). The increased risk of obesity associated with Ad36 infection was also significant (OR: 1.9; 95% CI: 1.01–3.56; P = 0.047). No significant differences were found in relation to total cholesterol (P = 0.83), triglycerides (P = 0.64), HDL (P = 0.69), blood glucose (P = 0.08), waist circumstance (P = 0.09), and systolic blood pressure (P = 0.25). Ad36 infection was associated with the risk of obesity and weight gain, but was not associated with abnormal metabolic markers including waist circumstance. It suggests that Ad36 infection is more associated with accumulation of subcutaneous fat than that of visceral fat. The relationship between Ad36 and obesity should be assessed by further studies, including well-designed prospective studies, to gain a better understanding of whether Ad36 plays a role in the etiology of human obesity.
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