Development of a centrifugal type mechanical circulatory support device TinyPump for infants and children

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A disposable, tiny centrifugal blood pump TinyPump having priming volume of 5 ml has been designed to support circulation of infants and children and its pump performance, durability and bio-compatibility were studied in vitro and in vivo. The TinyPump comprises of a 30mm diameter impeller having 6 straight vanes supported with a hydrodynamic bearing at its center and rotated by a radial magnetic coupling torque. In the cardiopulmonary bypass study using 3 Kg newborn piglets, the TinyPump showed superior performances in terms of hemo-dilution, hemolysis, and inflammatory responses. In the left ventricular assist experiments using 10 Kg Shiba-goats, the TinyPump revealed safe, stable circulatory support for the duration of 30 days in 3 animals. The TinyPump can provide safe and reliable circulatory support in the infants and children.