Comprehensive Basic Research for Development of Advanced, Innovative Permanent Artificial Heart Systems

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In this research, basic research covering following items was conducted ;1.In the pulsatile artificial heart that is based on the electromechanical principle, the durability of the roller screw mechanism was improved by coating the friction surface with a diamond-like-carbon coating. The ventricular assist device continued to operate for duration of 13 months in the 37 degree C bath. The failure in the ball bearing that supports the roller screw movement caused termination of the study.2.Magnetic levitation (MagLev) mechanism was investigated to achieve a mechanical contact-free centrifugal blood pump. A two-degree-freedom MagLev system was developed to attain a disposable extracorporeal blood pump and an implantable system. The power requirement in the MagLev system was reduced to less than 1.0watt with controllability being less than 20 micron meter. The hemolytic performance of the MagLev centrifugal blood pump was improved by a factor of 6-7 in comparison to the clinical standard B … More PX-80.3.The computational fluid dynamics (CFD) analysis was conducted to evaluate the mechanical design of the MagLev centrifugal blood pump designed in section 2. Flow visualization was also carried out to verify the numerical predictions to optimize the pump design.4.Basic research was also extended to evaluate the deformation and recovery response of red blood cells under cyclically reversing shear flow. A specially built shear flow generator was used to simulate a condition similar to that inside the centrifugal blood pumps. The results of the study can be used to improve the blood pump design.5.The optical reflectance sensor utilizing the fiber-optics was developed to detect thrombus formation inside the cardiovascular devices. Its application in oxygenators and blood pumps will be investigated.6.A surgical navigation system was developed to assist implantation of the artificial heart system. The CT images and CAD data of the device were used to construct the proper implantation scheme of the device in patients prior to surgery. The prototype was tested in calf for VAD implantation. Less