Comprehensive Basic Research for Development of Advanced, Innovative Permanent Artificial Heart Systems

开发先进、创新的永久人工心脏系统的综合基础研究

• 批准号: 14208103
• 负责人: TAKATANI Setsuo
• 金额: $ 33.61万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14208103/
• 关键词: Pulsatile Ventricular Assist Device; Total Artificial Heart; Magnetic levitated Centrifugal Blood Pump; Hydrodynamic Levitated Centrifugal Blood Pump; Computational Fluid Dynamics; Flow Visualization; Blood Cell Biomechanics; Optical Scattering; 解

In this research, basic research covering following items was conducted ;1.In the pulsatile artificial heart that is based on the electromechanical principle, the durability of the roller screw mechanism was improved by coating the friction surface with a diamond-like-carbon coating. The ventricular assist device continued to operate for duration of 13 months in the 37 degree C bath. The failure in the ball bearing that supports the roller screw movement caused termination of the study.2.Magnetic levitation (MagLev) mechanism was investigated to achieve a mechanical contact-free centrifugal blood pump. A two-degree-freedom MagLev system was developed to attain a disposable extracorporeal blood pump and an implantable system. The power requirement in the MagLev system was reduced to less than 1.0watt with controllability being less than 20 micron meter. The hemolytic performance of the MagLev centrifugal blood pump was improved by a factor of 6-7 in comparison to the clinical standard B … More PX-80.3.The computational fluid dynamics (CFD) analysis was conducted to evaluate the mechanical design of the MagLev centrifugal blood pump designed in section 2. Flow visualization was also carried out to verify the numerical predictions to optimize the pump design.4.Basic research was also extended to evaluate the deformation and recovery response of red blood cells under cyclically reversing shear flow. A specially built shear flow generator was used to simulate a condition similar to that inside the centrifugal blood pumps. The results of the study can be used to improve the blood pump design.5.The optical reflectance sensor utilizing the fiber-optics was developed to detect thrombus formation inside the cardiovascular devices. Its application in oxygenators and blood pumps will be investigated.6.A surgical navigation system was developed to assist implantation of the artificial heart system. The CT images and CAD data of the device were used to construct the proper implantation scheme of the device in patients prior to surgery. The prototype was tested in calf for VAD implantation. Less

本研究主要进行了以下几方面的基础研究：1.在基于机电原理的脉动式人工心脏中，通过在摩擦表面涂覆类金刚石涂层，提高了滚动丝杠机构的耐久性。心室辅助装置在37 ℃水浴中持续运行13个月。由于滚珠轴承的失效导致研究终止。2.研究了磁悬浮（MagLev）机制以实现机械无接触离心血泵。为实现一次性体外血泵和植入式系统，研制了一种二自由度磁悬浮系统。MagLev系统的功率要求降低到小于1.0瓦，可控性小于20微米。与临床标准B相比，MagLev离心血泵的溶血性能提高了6-7倍 ...更多信息 PX-80.3。进行计算流体动力学（CFD）分析，以评价第2节中设计的MagLev离心血泵的机械设计。通过流场可视化验证了数值预测的正确性，为泵的优化设计提供了依据。4.对循环往复剪切流作用下红细胞的变形和恢复响应进行了基础研究。使用专门构建的剪切流发生器来模拟与离心血泵内部类似的条件。研究结果可用于改进血泵的设计。5.研制了一种利用光纤的光学反射传感器，用于检测心血管装置内的血栓形成。本研究将探讨其在氧合器和血泵中的应用。6.研制了一种辅助人工心脏植入手术的手术导航系统。术前使用器械的CT图像和CAD数据构建器械在患者体内的适当植入方案。原型在小牛中进行了VAD植入试验。少

项目成果

Quantification of the Secondary Flow in a Radial Coupled Centrifugal Blood Pump Based on Particle Tracking Velocimetry

基于粒子跟踪测速的径向耦合离心血泵中二次流的量化

• 发表时间: 2005
• 期刊: Artif Organs 29-1
• 作者: Nobuo Watanabe;Tetsuo Fujimoto;et al.
• 通讯作者: et al.

Beyond implantable first generation cardiac prostheses for treatment of end-stage cardiac patients with clinical results in a multicenter.

超越可植入的第一代心脏假体，用于治疗终末期心脏病患者，并在多中心取得临床结果。

• 发表时间: 2002
• 期刊: Ann Thorac Cardiovasc Surg Oct;8(5)
• 作者: Takatani S

Measurement of the rotor motion and corresponding hemolysis of a centrifugal blood pump with a magnetic and hydrodynamic hybrid bearing.

• DOI: 10.1111/j.1525-1594.2005.29091.x
• 发表时间: 2005-07
• 期刊: Artificial organs
• 影响因子: 2.4
• 作者: H. Kataoka;Y. Kimura;H. Fujita;S. Takatani

Mechanical circulatory support devices (NCSD) in Japan : Current status and future direction.

日本的机械循环支持装置（NCSD）：现状和未来方向。

• 发表时间: 2005
• 期刊: J Artif Organs 8(1)
• 作者: Takatani S;Matsuda H;Hanatani A;Nojiri C;Yamazaki K;Motomura T;Ohuchi K;Sakamoto T;Yamane T.
• 通讯作者: Yamane T.

Magnetically levitated non-contact rotary centrifugal blood pump.

磁悬浮非接触式旋转离心血泵。

• 发表时间: 2004
• 期刊: Annual Reports of the Institute of Biomaterials and Bioengineering 38
• 作者: Asama J;Shinshi T;Hoshi H;Takatani S;Shimokohbe A.;Yasushi Oki;Takatani S.
• 通讯作者: Takatani S.