Structural analysis of genomic regions where genetic recombination was suppressed for over million years

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Goal of this study is to elucidate the structure and divergence of t-haplotype genome in which genetic recombination has been suppressed for over million years. Large scale DNA rearrangements including deletions and duplications were revealed by Array-CGH method, inferring the break points of inversions associated with t-haplotypes. BAC genomic library was constructed from tw5 haplotype, and clones corresponding to the t-complex region were isolated and sequenced. Exceptionally high incidence of SNPs (single nucleotide polymorphisms) has been detected between the tw5haplotype and the standard laboratory mouse strain.