Densign and Development of Stress Responsive LIPOzyme Reactor Based on Re-functionalization of Junk Peptides

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It is demonstrated that the function of LIPOzyme (Liposome+Enzyme) could be induced by the construction of catalytic sites on the liposome membrane as a model biomembrane. The LIPOzyme function could be classified by three categories : (i) electron transfer ; (ii) proton transfer ; (iii) nucleophilic/electrophilic reaction. The LIPOzyme function could be, herewith, controlled by the tuning of junk peptides, ligands or their metal complexes to achieve the desired function. Furthermore, the immobilization of LIPOzyme into the module was presented to develop the novel membrane module. This technique is a promising method to develop the reactor/separator based on the LIPOzyme function. Besides, the mapping of the physicochemical properties of junk peptides and the lipid composition could be performed to clarify the optimal condition for the desired functions of LIPOzyme, resulting in developing their database.