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Physiological and pathological roles of CD47-SHPS-1 system

Physiological and pathological roles of CD47-SHPS-1 system
CD47-SHPS-1系统的生理和病理作用
批准号:
20370044
负责人:
MATOZAKI Takashi
金额:
$13.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

MATOZAKI Takashi的其他基金

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中文摘要
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英文摘要
SHPS-1 and CD47 are transmembrane proteins and they constitute a cell-cell communication system by interacting their ectodomains. In this research project, we have shown that CD47-SHPS-1 system participates in regulation of brain stress response and depression-like behavior as well as induction of IL-17-producing helper T cells and autoimmune diseases. In addition, it also plays an important role in regulation of insulin secretion from pancreatic βcells.
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会议论文
腸管におけるSHPS-1発現と腸管免疫制御
SHPS-1在肠道中的表达与肠道免疫调节
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [金澤義丈, 齋藤泰之, ヤナ, スプリアトナ, 村田陽二, 岡澤秀樹, 大西浩史, 下瀬川透, 的崎尚]
通讯作者: 的崎尚
SAP-1 is an intestinal microvillus-specific protein tyrosine phosphatase that protects against colitis in cooperation with IL-10
SAP-1 是一种肠道微绒毛特异性蛋白酪氨酸磷酸酶,与 IL-10 配合可预防结肠炎
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [村田陽二、的崎尚, 他]
通讯作者:
Defective development of dendritic cells in SHPS-1 mutant mice
SHPS-1突变小鼠树突状细胞发育缺陷
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Saito, Y. et. al.]
通讯作者: Y. et. al.
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: []
通讯作者:
64
    Molecular basis for regulation of the cellular life span
    • 批准号:
      23659155
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      MATOZAKI Takashi
    • 依托单位:
    The integrative research for regulation by protein tyrosine phosphatases of biological functions and its molecular mechanism
    • 批准号:
      23370061
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.9万
    • 财政年份:
      2011
    • 负责人:
      MATOZAKI Takashi
    • 依托单位:
    Physiological roles of CD47-SHPS-1 system, an intercellular signaling, in regulation of various cellular functions
    • 批准号:
      18370054
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.05万
    • 财政年份:
      2006
    • 负责人:
      MATOZAKI Takashi
    • 依托单位:
    Protein tyrosine phosphatases and regulation of cancer cell adhesion/migration
    • 批准号:
      17014010
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $43.46万
    • 财政年份:
      2005
    • 负责人:
      MATOZAKI Takashi
    • 依托单位: