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Molecular basis for regulation of the cellular life span

Molecular basis for regulation of the cellular life span
调节细胞寿命的分子基础
批准号:
23659155
负责人:
MATOZAKI Takashi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

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中文摘要
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英文摘要
Cells constituting organs in the mammals have cell-type-specific life span after their terminal differentiation. The differences in cellular life span are though to be dependent on cell characteristics and functions. However, the molecular basis underlying the regulation of the life span of terminally differentiated cells is not fully elucidated. Moreover, the biological significance of cell-type-specific life span still remains unclear. To clarify the mechanism of the regulation of cellular life span, we performed approaches using mouse intestinal epithelial cells as a model.
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脾臓T細胞の恒常性調節へのSIRPαの関与
SIRPα 参与脾 T 细胞稳态调节
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kuboyama T., Tohda C., Komatsu K., 堀 修, 榎戸 靖, 東田千尋, 橋本(佐藤)美穂 他]
通讯作者: 橋本(佐藤)美穂 他
Dendritic cell-specific depletion of protein tyrosine phosphatase Shp1 promotes Th1 differentiation causes autoimmunity
树突状细胞特异性消耗蛋白酪氨酸磷酸酶Shp1促进Th1分化导致自身免疫
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kaneko T., Matozaki, T., et al.]
通讯作者: et al.
細胞質型チロシンホスファターゼShp2の成熟脳における機能解析
成熟脑细胞质酪氨酸磷酸酶Shp2的功能分析
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [草苅伸也, 橋本美穂, 柴崎貢志, 吾郷由希夫, 松田敏夫, Benjamin G. Neel, 小谷武徳, 村田陽二, 的崎尚, 大西浩史]
通讯作者: 大西浩史
Regulation of brain functions by a protein tyrosine phosphatase Shp2
蛋白酪氨酸磷酸酶 Shp2 对大脑功能的调节
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kusakari S. et al.]
通讯作者: Kusakari S. et al.
23
    The integrative research for regulation by protein tyrosine phosphatases of biological functions and its molecular mechanism
    • 批准号:
      23370061
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.9万
    • 财政年份:
      2011
    • 负责人:
      MATOZAKI Takashi
    • 依托单位:
    Physiological and pathological roles of CD47-SHPS-1 system
    • 批准号:
      20370044
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $13.23万
    • 财政年份:
      2008
    • 负责人:
      MATOZAKI Takashi
    • 依托单位:
    Physiological roles of CD47-SHPS-1 system, an intercellular signaling, in regulation of various cellular functions
    • 批准号:
      18370054
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.05万
    • 财政年份:
      2006
    • 负责人:
      MATOZAKI Takashi
    • 依托单位:
    Protein tyrosine phosphatases and regulation of cancer cell adhesion/migration
    • 批准号:
      17014010
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $43.46万
    • 财政年份:
      2005
    • 负责人:
      MATOZAKI Takashi
    • 依托单位:
    海外基金