Selection of prebiotic building blocks by cyclic phase transitions (A06)

通过循环相变选择益生元构建模块（A06）

• 批准号: 537066374
• 金额: --
• 依托单位: Institut für Physik
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/537066374?language=en
• 关键词: Selection; prebiotic; building; blocks; cyclic

We develop the non-equilibrium thermodynamic theory to investigate the selection propensity of cyclic phase transitions (freeze-thaw or liquid-liquid co-existance) for the assembly of building blocks essential to life. Specifically, we will apply our theory to minimalistic auto-catalytic reactions, the formation of long homopolymeric linear aggregates such as fatty acids, and the formation of DNA and RNA. We will determine the optimal physicochemical conditions for different cycle properties to obtain specific replication rates, length distributions, and sequence distributions. Our project is fundamental for future studies that screen for functional sequences capable of simple folds or complex functionalities such as self-replication.

我们发展了非平衡态热力学理论来研究循环相变（冻融或液-液共存）对生命基本构件组装的选择倾向。具体来说，我们将把我们的理论应用于最小化的自催化反应，形成长的均聚线性聚集体，如脂肪酸，以及DNA和RNA的形成。我们将确定不同循环特性的最佳物理化学条件，以获得特定的复制率，长度分布和序列分布。我们的项目是未来研究的基础，筛选功能序列能够简单的折叠或复杂的功能，如自我复制。