転写・RNAプロセシング・輸送の機能的連携と統合による遺伝子発現調節機構の解明

最近出现的证据表明，在活细胞中存在转录、前mRNA剪接和核mRNA输出之间的功能联系，该联系已被独立分析。然而，这种连锁的分子机制尚不清楚。在本研究中，我们分析了导致前mRNA剪接缺陷和细胞核mRNA输出的裂变酵母突变的相关基因，并阐明了真核细胞中基因表达协调调控的部分分子机制。

Recent emerging evidence suggested that a functional linkage among transcription, pre-mRNA splicing and nuclear mRNA export, which had been analyzed independently, exists in a living cell. However, the molecular mechanism of the linkage still remains unclear. In this study, we analyzed the genes responsible for the fission yeast mutations that cause defective pre-mRNA splicing and nuclear mRNA export, and elucidated a part of the molecular mechanism of coordinated regulation of gene expression in eukaryotic cells.