転写・RNAプロセシング・輸送の機能的連携と統合による遺伝子発現調節機構の解明

点击翻译按钮获取中文摘要

Recent emerging evidence suggested that a functional linkage among transcription, pre-mRNA splicing and nuclear mRNA export, which had been analyzed independently, exists in a living cell. However, the molecular mechanism of the linkage still remains unclear. In this study, we analyzed the genes responsible for the fission yeast mutations that cause defective pre-mRNA splicing and nuclear mRNA export, and elucidated a part of the molecular mechanism of coordinated regulation of gene expression in eukaryotic cells.