Analyses on the nuclear structures regulating the alternative splicingspatiotemporally using bioprobes

在真核细胞中，细胞核被高度划分为几十个核结构。真核细胞中的基因表达是通过这些核结构协调调节的。在这项研究中，我们利用从放线菌培养物中分离的抑制核结构形成的化合物作为生物探针，分析了基因转录后调控的机制，如选择性剪接和核mRNA输出，通过核结构进行时空调控

In eukaryotic cells, the nucleus is highly compartmentalized with dozens of nuclearstructures. Gene expression in the eukaryotic cells is co-ordinately regulated via thosenuclear structures. In this study, we analyzed the mechanisms of the post-transcriptionalregulation of gene expression, such as alternative splicing and nuclear mRNA export,conducted spatiotemporally via the nuclear structures, using the compounds isolated fromcultures of the actinomycetes, which inhibit the formation of the nuclear structures,as biological probes