Molecular mechanism of adhesion and deadhesion of endothelial cells required for angiogenesis
Molecular mechanism of adhesion and deadhesion of endothelial cells required for angiogenesis
批准号:
20370083
负责人:
MOCHIZUKI Naoki
金额:
$13.31万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Angiopopoetin-1(Ang1)-Tie2 signal promotes the expression of Kruppel-like factor 2 that is known to be a transcription factor essential for vascular quiescence. In addition, Ang1/Tie2 induces Dll4 expression by inhibiting degradation of beta-catenin in a manner dependent on AKT. Dll4/Notch signal upon cell-cell contacts is believed to inhibit VEGF-VEGFR2 signal. Collectively, Ang1/Tie2 signal stabilizes endothelial cells by inhibiting VEGF-VEGFR2 signal.
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DOI:
10.1161/circresaha.107.170191
发表时间:
2008-02
期刊:
Circulation research
影响因子:
20.1
作者:
[N. Mochizuki;Young-Guen Kwon]
通讯作者:
N. Mochizuki;Young-Guen Kwon
PSFl, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.
PSF1是在干细胞和祖细胞中广泛表达的DNA复制因子,驱动致瘤和转移特性。
DOI:
--
发表时间:
2010
期刊:
Cancer Res. 70
影响因子:
--
作者:
[Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N.]
通讯作者:
Takakura N.
A ngiopoietin-1/Tie2- mediated vascular maturation and quiescence are reregulate by Dll4-Notch signaling.
Ngiopoietin-1/Tie2 介导的血管成熟和静止由 Dll4-Notch 信号传导重新调节。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[長沼孝雄, 佐々木保典, 中川真一, 廣瀬哲郎, 三好知一郎, Naoki Mochizuki]
通讯作者:
Naoki Mochizuki
DOI:
10.1158/0008-5472.can-09-3662
发表时间:
2010-02-01
期刊:
CANCER RESEARCH
影响因子:
11.2
作者:
[Nagahama, Yumi, Ueno, Masaya, Takakura, Nobuyuki]
通讯作者:
Takakura, Nobuyuki
Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of {beta}-Catenin.
Angiopoietin-1/Tie2 信号增强基底 Notch 信号,通过 AKT 介导的 {β}-Catenin 激活诱导 Delta-Like 4 表达来控制血管静止。
DOI:
--
发表时间:
2011
期刊:
J.Biol.Chem. 286
影响因子:
--
作者:
[笠原広介, 稲垣昌樹, Zhang J.]
通讯作者:
Zhang J.
共 17 条
Deciphering the function for S1P transporter, Spns2, in mammals
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批准号:24370084
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.73万
-
财政年份:2012
-
负责人:MOCHIZUKI Naoki
-
依托单位:
G protein-regulated trafficking analyzed by bio-imaging
-
批准号:17079009
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$40.64万
-
财政年份:2005
-
负责人:MOCHIZUKI Naoki
-
依托单位:
Rap1-and R-Ras-regulated vascular endothelial cell-cell adhesion
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批准号:17370075
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.02万
-
财政年份:2005
-
负责人:MOCHIZUKI Naoki
-
依托单位:
Intracellular and intercellular signaling mediated by Eph tyrosine kinase receptor in vascular endothelial cells
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批准号:14380342
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.6万
-
财政年份:2002
-
负责人:MOCHIZUKI Naoki
-
依托单位:
海外基金