Molecular mechanism of adhesion and deadhesion of endothelial cells required for angiogenesis

血管生成所需内皮细胞粘附和死粘附的分子机制

• 批准号: 20370083
• 负责人: MOCHIZUKI Naoki
• 金额: $ 13.31万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20370083/
• 关键词: シグナル伝達; 細胞間接着; 血管新生; 細胞接着; GTP結合蛋白質; 血管内皮細胞

Angiopopoetin-1(Ang1)-Tie2 signal promotes the expression of Kruppel-like factor 2 that is known to be a transcription factor essential for vascular quiescence. In addition, Ang1/Tie2 induces Dll4 expression by inhibiting degradation of beta-catenin in a manner dependent on AKT. Dll4/Notch signal upon cell-cell contacts is believed to inhibit VEGF-VEGFR2 signal. Collectively, Ang1/Tie2 signal stabilizes endothelial cells by inhibiting VEGF-VEGFR2 signal.

血管生成素-1（Ang 1）-Tie 2信号促进Kruppel样因子2的表达，Kruppel样因子2已知是血管静止所必需的转录因子。此外，Ang 1/Tie 2通过以依赖于AKT的方式抑制β-连环蛋白的降解来诱导Dll 4表达。细胞-细胞接触后的Dll 4/Notch信号被认为抑制VEGF-VEGFR 2信号。总之，Ang 1/Tie 2信号通过抑制VEGF-VEGFR 2信号稳定内皮细胞。

项目成果

15-lipoxygenase-1 in the vasculature: expanding roles in angiogenesis.

• DOI: 10.1161/circresaha.107.170191
• 发表时间: 2008-02
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: N. Mochizuki;Young-Guen Kwon

PSFl, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.

PSF1是在干细胞和祖细胞中广泛表达的DNA复制因子，驱动致瘤和转移特性。

• 发表时间: 2010
• 期刊: Cancer Res. 70
• 作者: Nagahama Y;Ueno M;Miyamoto S;Morii E;Minami T;Mochizuki N;Saya H;Takakura N.
• 通讯作者: Takakura N.

A ngiopoietin-1/Tie2- mediated vascular maturation and quiescence are reregulate by Dll4-Notch signaling.

Ngiopoietin-1/Tie2 介导的血管成熟和静止由 Dll4-Notch 信号传导重新调节。

• 发表时间: 2010
• 作者: 長沼孝雄;佐々木保典;中川真一;廣瀬哲郎;三好知一郎;Naoki Mochizuki
• 通讯作者: Naoki Mochizuki

PSF1, a DNA Replication Factor Expressed Widely in Stem and Progenitor Cells, Drives Tumorigenic and Metastatic Properties

• DOI: 10.1158/0008-5472.can-09-3662
• 发表时间: 2010-02-01
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Nagahama, Yumi;Ueno, Masaya;Takakura, Nobuyuki
• 通讯作者: Takakura, Nobuyuki

Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of {beta}-Catenin.

Angiopoietin-1/Tie2 信号增强基底 Notch 信号，通过 AKT 介导的 {β}-Catenin 激活诱导 Delta-Like 4 表达来控制血管静止。

• 发表时间: 2011
• 期刊: J.Biol.Chem. 286
• 作者: 笠原広介;稲垣昌樹;Zhang J.
• 通讯作者: Zhang J.