Studies on plant factors required for nonhost resistance against anthracnose fungi

拟南芥lic1突变体被非适应性病原体引起病变，导致突变体的基因编码一种功能未知的MACPF结构域蛋白。在这项研究中，我们发现lic1突变体的病变发展不是由于病原体进入，这表明在非宿主防御中，lic1是调节细胞死亡所必需的，并且依赖于pen2的抗微生物代谢物的合成参与了lic1介导的细胞死亡调节。我们还发现LIC1定位于质膜，并与LIC1同源物一起起作用。此外，我们发现EDR1和GSH1参与了非宿主抗性。

The Arabidopsis lic1 mutants developed lesions by non-adapted pathogens, and the gene responsible for the mutants encodes a MACPF domain protein with unknown function. In this study, we showed that lesion development in the lic1 mutants is not due to pathogen entry, indicating that LIC1 is required for regulation of cell death in nonhost defense, and that PEN2-dependent synthesis of anti-microbial metabolite is involved in LIC1-mediated regulation for cell death. We also indicate that LIC1 is localized in plasma membrane, and functions together with LIC1 homologs. Furthermore, we found that EDR1 and GSH1 are involved in nonhost resistance.