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Development of a novel therapy for canine atopic dermatitis with chimera IgG of anti-canine IgE antibody

Development of a novel therapy for canine atopic dermatitis with chimera IgG of anti-canine IgE antibody
抗犬IgE抗体嵌合IgG开发治疗犬特应性皮炎的新疗法
批准号:
20380172
负责人:
MAEDA Sadatoshi
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We tried to produce anti-canine IgE antibodies that could inhibit a binding of IgE to mast cells in order to develop a novel therapy for canine atopic dermatitis. Ten clones of the antibodies were generated by immunization of recombinant protein of the mast cell binding sites of IgE. The present results indicated that the antibodies could not inhibit a binding IgE to mast cells and also an allergen-mediated degranulation.
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Der f 1 enhances proinflammatory cytokine and chemokine gene expression in a cell line of canine epidermal keratinocytes
Der f 1 增强犬表皮角质形成细胞系中促炎细胞因子和趋化因子基因的表达
DOI: --
发表时间: 2009
期刊: Veterinary Immunology and Immunopathology 131
影响因子: --
作者: [Sone H, Imanishi S, Akanuma H, Nagano R, Fukuda T, Ohsako S, Sadatoshi MAEDA (Shingo MAEDA)]
通讯作者: Sadatoshi MAEDA (Shingo MAEDA)
Effect of recombinant canine IFN-gamma on GM-CSF, TGF-beta and CCL17 mRNA transcription in canine keratinocytes cell line (CPEK)
重组犬 IFN-γ 对犬角质形成细胞系 (CPEK) GM-CSF、TGF-β 和 CCL17 mRNA 转录的影响
DOI: --
发表时间: 2010
期刊: Veterinary Dermatology (In press)
影响因子: --
作者: [Pathirana IN, Kawate N, Tsuji M, Takahashi M, Hatoya S, Inaba T, Tamada H, Sadatoshi MAEDA (Sanae Shibata)]
通讯作者: Sadatoshi MAEDA (Sanae Shibata)
イヌの上皮向性リンパ腫病変部におけるリンパ球遊走関連分子の遺伝子発現解析
犬亲上皮性淋巴瘤病灶中淋巴细胞迁移相关分子基因表达分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Mito K, Sugiura K, Ueda K, Hori T, Akazawa T, Yamate J, Hatoya S, Inaba M, Inoue N, Ikehara S, Inaba T, 千村直輝(前田貞俊)]
通讯作者: 千村直輝(前田貞俊)
Augmentation of CCL17 and CCL28 gene expression by TNF-alpha, IL-1beta, or IFN-gamma in cultured canine keratinocytes
TNF-α、IL-1β 或 IFN-γ 在培养的犬角质形成细胞中增强 CCL17 和 CCL28 基因表达
DOI: --
发表时间: 2010
期刊: Research in Veterinary Science (In press)
影响因子: --
作者: [Hidetaka Nishida, et al, Sadatoshi MAEDA (Sanae SHIBATA)]
通讯作者: Sadatoshi MAEDA (Sanae SHIBATA)
15
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    • 批准号:
      15K14869
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
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    • 负责人:
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