Suppression of platelet aggregation mediated by metastasis-promoting Aggrus protein

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We have previously identified Aggrus protein as a metastasis-promoting platelet aggregation-inducing factor expressed on the surface of metastatic tumor cells. We established 5 different monoclonal antibodies (mAbs) recognizing human Aggrus protein and found that a mAb suppressed Aggrus-mediated platelet aggregation. We also identified a tetraspanin family CD9 protein as an Aggrus-inhibitory binding protein. Using in vivo imaging system, we successfully visualized the effect of CD9 on pulmonary metastasis and lung retention of GFP-expressing tumor cells.