Studies on regulation of matrix ion dynamics and energy metabolism by mitochondria NCX

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The aim of this study was quantitative elucidation of physiological function of mitochondria. Mitochondrial and cytoplasmic Ca dynamics were studied by using Ca-sensitive fluorescent dyes in cardiac myocytes. Based on these data and previously published data, a mathematical model of mitochondria which can well reproduce mitochondrial Ca, Na and H changes was newly developed. A comprehensive mitochondria model was accomplished by integrating the model with the metabolic model including oxidative phosphorylation and TCA cycle. It was suggested that Ca- and phosphate-dependent regulatory processes are important in keeping the balance of energy metabolites.