Analysis of cell fate determination of vertebrate retinal photoreceptor cells

视觉对我们的生活至关重要。阐明视网膜光感受器细胞发育的分子机制不仅对生物学研究具有重要意义，而且对视网膜疾病的诊断和治疗具有重要意义。我们主要利用小鼠遗传学研究视网膜感光细胞发育的机制。我们在视网膜干细胞增殖、分化和维持感光细胞、双极细胞功能以及相关人类疾病的分子机制方面取得了进展。

Vision is critical to our lives. To elucidate molecular mechanisms underlying development of retinal photoreceptor cells is not only important for biology but also for development of diagnosis and treatment of retinal diseases. We studied mechanisms of retinal photoreceptor development mainly by using mouse genetics. We progressed our understanding on molecular mechanisms underlying retinal stem cell proliferation, differentiation and maintenance of photoreceptor cells, function and related human diseases of bipolar cells.