Regulation mechanisms of mTOR-mediated nutrient signaling by protein phosphatase PP2A

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We studied the involvement of the protein dephosphorylation reaction in the regulation of the protein kinase named mTOR, that senses the intracellular concentrations of amino acids to control cell proliferation. It was revealed that mTIP41, a regulator of the protein dephosphorylation reaction, enhances the mTOR signaling pathway by not only suppressing the dephosphorylation of mTOR substrates but also playing a role in the upstream of the mTOR protein kinase. These results of nutrient signaling are important to elucidate the cellular regulation mechanisms by amino acids.