Diagnostic Performances and Cost-effectiveness of Screening Programs for Hepatitis C Virus-related Hepatocellular Carcinoma

从成本-效果的角度来看，在丙型肝炎病毒相关性肝硬变的长期随访期间，病例发现程序对检测肝细胞癌的意义是有争议的问题。AFP和DCP的诊断特点对发现肝细胞癌的早期诊断价值较低。肝细胞癌监测项目应以合理的边际成本-效果比估计延长预期寿命，但应进行结构敏感性分析以确认结果的稳健性。

The significance of case-finding programs to detect hepatocellular carcinoma developed during the long-term follow-up of Hepatitis C Virus-related cirrhosis are controversial issues from the viewpoints of cost-effectiveness. Diagnostic characteristics of AFP and DCP had low performances to find the early stage of hepatocellular carcinoma. The surveillance programs for hepatocellular carcinoma should estimate to prolong life expectancy at a reasonable marginal cost-effectiveness ratio, however, structural sensitivity analysis should be performed to confirm the robustness of the results.