Screening molecular markers for prediction of recurrence and prognosis of colorectal cancer.

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To identify gene sets for prediction of prognosis or for prediction of efficacy of anticancer drugs in metastatic colorectal cancer (mCRC), mRNA were extracted from tumor tissues of mCRC and were analyzed for oligonucleotide microarray. We found that mCRC were clustered into 3 large clusters. Further, these clusters were correlated with KRAS status and efficacy of chemotherapy with or without anti-EGFR antibody. We are now extracting gene sets for prediction of efficacy of specific anticancer drug or regimen.