Involvement of iron metabolism in cadmium toxicity and elucidation of its molecular mechanism

镉通过抑制妊娠小鼠十二指肠铁转运相关基因（DMT1、FPN1、DCYTB）的表达来抑制铁的吸收。结果表明，胎儿生长受到抑制。此外，镉还抑制了成年小鼠十二指肠铁转运相关基因（DMT1、FPN1、DCYTB、HEPH、HCP1）的表达，影响了肠道铁的吸收。此外，镉还抑制了培养肠上皮细胞中铁转运相关基因（DMT1、FPN1、DCYTB、HEPH）的表达。

Cadmium inhibited iron absorption through suppression of the expression of genes (DMT1、FPN1、DCYTB) related to iron transport in the duodenum of pregnant mice. As a result, it was shown that fetal growth was inhibited. Furthermore, cadmium was found to suppress the expression of genes (DMT1, FPN1, DCYTB, HEPH, HCP1) related to iron transport in the duodenum of adult mice and to affect on the intestinal iron absorption. In addition, cadmium was also shown to inhibit the expression of genes (DMT1, FPN1, DCYTB, HEPH) related to iron transport in cultured intestinal epithelial cells.