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Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease

Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease
心脏特异性单分子的鉴定和功能分析及其在心血管疾病中的治疗应用
批准号:
20390225
负责人:
TAKASHIMA Seiji
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In this research project, I newly discovered GS protein whose expression is regulated specifically different way in the cardiomyocyte. GS regulates the function of ATP synthesis. We also purified and identified a new AMPK substrate; CLIP-170 and clarified the regulatory role of AMPK in microtubule polymerization. Both discoveries lead to the understanding of novel cellular stress response in cardiomyocyte and the therapeutic approach of the cardiovascular diseases.
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会议论文
DOI: 10.1291/hypres.31.1977
发表时间: 2008-10
期刊: Hypertension Research
影响因子: 5.4
作者: [Hui Zhao;Y. Liao;T. Minamino;Y. Asano;M. Asakura;Jiyoong Kim;H. Asanuma;S. Takashima;M. Hori;M. Kitakaze]
通讯作者: Hui Zhao;Y. Liao;T. Minamino;Y. Asano;M. Asakura;Jiyoong Kim;H. Asanuma;S. Takashima;M. Hori;M. Kitakaze
DOI: 10.1016/j.bbrc.2010.01.076
发表时间: 2010-02-26
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [Min, Kyung-Duk, Asakura, Masanori, Kitakaze, Masafumi]
通讯作者: Kitakaze, Masafumi
Methamphetamine directly accelerates beating rate in cardiomyocytes by increasing Ca2+ entry via L-type Ca2+ channel
甲基苯丙胺通过 L 型 Ca2 通道增加 Ca2 进入,直接加速心肌细胞的跳动率
DOI: --
发表时间: 2009
期刊: Biochemical and Biophysical Research Communications 390
影响因子: --
作者: [Sugimoto, K., Okamura, K., Tanaka, H., Takashima, S., Ochi, H., Yamamoto, T., Matoba, R.]
通讯作者: R.
Identification of a novel substrate for TNFalpha-induced kinase NUAK2.
TNFα 诱导的激酶 NUAK2 的新型底物的鉴定。
DOI: --
发表时间: 2008
期刊: Biochem Biophys Res Commun. 365(3)
影响因子: --
作者: [Yamamoto H, Takashima S, Shintani Y, Yamazaki S, Seguchi O, Nakano A, Higo S, Kato H, Liao Y, Asano Y, Minamino T, Matsumura Y, Takeda H, Kitakaze M.]
通讯作者: Kitakaze M.
22
    Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development
    • 批准号:
      15H04820
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.15万
    • 财政年份:
      2015
    • 负责人:
      TAKASHIMA Seiji
    • 依托单位:
    Development of simple and noninvasive method to assess the severity of heart failure
    • 批准号:
      26670402
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2014
    • 负责人:
      TAKASHIMA Seiji
    • 依托单位:
    Role of aPKC molecules in spermatogonial stem cell homing
    Production ofgene-modified animalbytransposase-mediated gene transduction into spermatogonial stem cells.
    • 批准号:
      22790379
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.5万
    • 财政年份:
      2010
    • 负责人:
      TAKASHIMA Seiji
    • 依托单位:
    海外基金