Elucidation of molecular mechanisms regulating the gene expression of fetal cardiac ion channels and its implication as a novel therapeutic target for the treatment of heart failure

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Genetic remodeling contributes to the progression of pathological cardiac remodeling and heart failure by affecting myocardial cellular function and survival. In this study we evaluated the transcriptional regulation of fetal cardiac ion channels gene expression and the significance of these fetal ion channels as novel therapeutic targets for the treatment and prevention of heart failure. Our studies have revealed the transcriptional network regulating the expression of cardiac fetal-type ion channels, which are involved in the development of cardiac dysfunction and arrhythmias and potential therapeutic targets for the treatment and prevention of heart failure.