Elucidation of transcriptional and epigenomic regulation in the development of heart failure

我们研究了心力衰竭发展过程中心脏基因表达的转录和表观基因组调控。我们发现NRSF-HDAC复合体通过调节HCN_2和4个离子通道的表达来维持心脏的电稳定性。此外，我们还揭示了Rho依赖的SRF共激活因子MRTF-A在病理性心脏重构中的重要作用。此外，我们还分析了TRPC3/6抑制对病理性心脏重构的治疗作用。

We examined the transcriptional and epigenomic regulation of cardiac gene expression during the development of heart failure. We found that NRSF-HDAC complex maintains cardiac electrostability by regulating HCN2 and 4 ion channels expression. In addition, we revealed the important role played by MRTF-A, a rho-dependent co-activator of SRF, in pathological cardiac remodeling. Furthermore, we analyzed the therapeutic effect of TRPC3/6 inhibition on pathological cardiac remodeling.