Investigation of the genes associated with bone mineral density by high-density SNP chip analysis in a large cohort study
Investigation of the genes associated with bone mineral density by high-density SNP chip analysis in a large cohort study
批准号:
20390264
负责人:
TAKAYANAGI Ryoichi
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
为了探索与日本女性骨密度(BMD)相关的候选基因,我们在一个大型社区队列中进行了一项全基因组关联研究(GWAS)。研究对象是绝经后的妇女,没有服用任何药物,没有任何疾病或妇科病史。GWAS和随后的分析发现了几个与日本女性骨密度相关的候选基因。
英文摘要
To explore candidate g:enes associated with bone mineral density(BMD) of Japanese women, we performed a genome-wide association study(GWAS) in a large community-based cohort. The study subjects were postmenopausal women without taking any drugs, having any diseases or gynecological history. The GWAS and the following analyses uncovered several candidate genes to be associated with BMD in Japanese women.
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アンドロゲン、エストロゲンと骨代謝マーカー
雄激素、雌激素和骨代谢标志物
DOI:
--
发表时间:
2009
期刊:
CLINICAL CALCIUM 19(8)
影响因子:
--
作者:
[大中佳三, 高柳涼一]
通讯作者:
高柳涼一
DOI:
10.2337/dc08-0297
发表时间:
2008-08-01
期刊:
DIABETES CARE
影响因子:
16.2
作者:
[Nanri, Akiko, Mizoue, Tetsuya, Takayanagi, Ryoichi]
通讯作者:
Takayanagi, Ryoichi
シンポジウム「酸化ストレスと抗酸化システム」-「ビリルビンの抗酸化作用と生活習慣病」
研讨会“氧化应激与抗氧化系统”-“胆红素的抗氧化作用与生活方式相关疾病”
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ikubo, M., Wada, T., Asano, T., 大中佳三]
通讯作者:
大中佳三
Inverse associations of serum bilirubin with C-reactive protein, glycated he moglobin, and prevalence of diabetes mellitus in middle-aged and elderly Japanese men and women
日本中老年男性和女性血清胆红素与C反应蛋白、糖化血红蛋白和糖尿病患病率的负相关
DOI:
--
发表时间:
2010
期刊:
Diabetes Res Clin Pract
影响因子:
--
作者:
[Ohnaka K, Kono S, Inoguchi T, Yin G, Morita M, Adachi M, Kawate H, Takayanagi R.]
通讯作者:
Takayanagi R.
DOI:
10.1016/j.mce.2010.01.006
发表时间:
2010-05-05
期刊:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
影响因子:
4.1
作者:
[Gushima, Mika, Kawate, Hisaya, Takayanagi, Ryoichi]
通讯作者:
Takayanagi, Ryoichi
共 9 条
Elucidation of the mechanism of glucocorticoid-induced osteoporosis by suppression of Wnt signaling pathway and the development of prediction method at its preclinical stage
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批准号:17390272
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.16万
-
财政年份:2005
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负责人:TAKAYANAGI Ryoichi
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依托单位:
Detection system for post-receptor disorders by three-dimensional imaging
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批准号:14370330
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:2002
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负责人:TAKAYANAGI Ryoichi
-
依托单位:
Establishment of the concept of androgen insensitivity syndrome due to the abnormality of transcriptional cofactor and analysis of the responsible cofactor.
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批准号:10671037
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1998
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负责人:TAKAYANAGI Ryoichi
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依托单位:
Analysis of the processing mechanism of endothelin-converting enzyme and the development of its inhibitors as novel therapeutics for vascular complications.
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批准号:08671167
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1996
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负责人:TAKAYANAGI Ryoichi
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依托单位:
Purification and structure analysis of endothelin-converting enzyme.
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批准号:04671488
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1992
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负责人:TAKAYANAGI Ryoichi
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依托单位:
海外基金