Roles of leukemogenic oncogenes in the regulation of metabolism, growth, and differentiation of hematopoietic stem cells

致白血病癌基因在造血干细胞代谢、生长和分化调节中的作用

• 批准号: 20390269
• 负责人: MATSUMURA Itaru
• 金额: $ 11.9万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390269/
• 关键词: 造血幹細胞; 遺伝子変異; 慢性骨髄性白血病; 活性型チロシンキナーゼ; 増殖シグナル; 自己複製; 白血病; エネルギー代謝; SIRT1

1. The C-terminal deletion mutant of RUNX1, RUNX1dC, attenuates DNA-damage repair responses to UV irradiation in murine c-KIT^+Sca-1^+Lin^- cells by suppressing the expression of Gadd45a.2. FIP1L1-PDGFRalpha not only enhanced the development of eosinophil progenitors (EoPs) from KSL cells but also aberrantly developed EoPs from progenitors in other lineages.3.BCR-ABL inhibited erythropoiesis through the induction of p21^<WAF1> via Ras/MAPK, while it promoted granulopoiesis.

1.RUNX1的C端缺失突变体RUNX1dC通过抑制Gadd45a2的表达，减弱了小鼠c-kit^+Sca-1^+Lin^-细胞对紫外线辐射的DNA损伤修复反应。FIP1L1-PDGFRpha不仅能促进KSL细胞的嗜酸性粒细胞祖细胞(EOPs)的发育，而且还能使其他细胞系的EOPs发生异常。3.BCR-ABL通过RAS/MAPK途径诱导p21^&lt；WAF1&GT；抑制红细胞生成，促进粒系生成。

项目成果

AML1/RUNX1 Works as a Negative Regulator of c-Mpl in Hematopoietic Stem Cells

• DOI: 10.1074/jbc.m804768200
• 发表时间: 2008-10-31
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Satoh, Yusuke;Matsumura, Itaru;Kanakura, Yuzuru
• 通讯作者: Kanakura, Yuzuru

Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies

• DOI: 10.1111/j.1349-7006.2007.00717.x
• 发表时间: 2008-03
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: I. Matsumura;M. Mizuki;Y. Kanakura

Antifungal Activity of Micafungin in Serum

• DOI: 10.1128/aac.01404-08
• 发表时间: 2009-10-01
• 期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
• 影响因子: 4.9
• 作者: Ishikawa, Jun;Maeda, Tetsuo;Kanakura, Yuzuru
• 通讯作者: Kanakura, Yuzuru

BCR-ABL but Not JAK2 V617F Inhibits Erythropoiesis through the Ras Signal by Inducing p21CIP1/WAF1*

• DOI: 10.1074/jbc.m110.118653
• 发表时间: 2010-07
• 期刊: The Journal of Biological Chemistry
• 作者: M. Tokunaga;S. Ezoe;Hirokazu Tanaka;Yusuke Satoh;K. Fukushima;K. Matsui;Masaru Shibata;Akira Tanimura;K. Oritani;I. Matsumura;Y. Kanakura

FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.

FIP1L1-PDGFRalpha 将嗜酸性粒细胞谱系定型强加于造血干/祖细胞。

• 发表时间: 2009
• 期刊: J Biol Chem 284
• 作者: Fukushima K;Matsumura I;Kanakura Y (10人中10番目)
• 通讯作者: Kanakura Y (10人中10番目)