课题基金 / 基金详情

Generation of hematopoietic cells and immune cells from iPS cells

Generation of hematopoietic cells and immune cells from iPS cells
从 iPS 细胞产生造血细胞和免疫细胞
批准号:
20390296
负责人:
HEIKE Toshio
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

HEIKE Toshio的其他基金

相似基金

相关文献

中文摘要
翻译
在小鼠iPS细胞中,我们鉴定了Flk-1(+)细胞作为血血管生成祖细胞,即“成血管细胞”,分化为成熟的红细胞,并分析了它们的功能。我们还从人iPS细胞建立了中性粒细胞分化系统。iPS细胞来源的中性粒细胞具有成熟中性粒细胞的形态和功能特征,并追踪类似于骨髓造血的分化过程。
英文摘要
In murine iPS cells, we identified the Flk-1(+) cells as the hemoangiogenic progenitors, "hemangioblasts", differentiated mature erythrocytes and analyzed their functions. We also established a neutrophil differentiation system from human iPS cells. The iPS cell-derived neutrophils were equipped with morphological and functional characteristics of mature neutrophils and traced the differentiation process similar to bone marrow hematopoiesis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Orderly hematopoietic development of induced pluripotent stem cells via Flk-1(+) hemoangiogenic progenitors.
通过 Flk-1( ) 血管生成祖细胞诱导多能干细胞有序造血发育。
DOI: --
发表时间: 2009
期刊: J Cell Physiol. 221(2)
影响因子: --
作者: [Niwa A, Umeda K, Chang H, Saito M, Okita K, Takahashi K, Nakagawa M, Yamanaka S, Nakahata T, Heike T.]
通讯作者: Heike T.
Neutrophil differentiation from human induced pluripotent stem(iPS)cells for disease investigation
人类诱导多能干 (iPS) 细胞分化中性粒细胞用于疾病研究
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Morishima T, Nakahata T., 他4名]
通讯作者: 他4名
DOI: 10.1096/fj.09-137174
发表时间: 2010-07-01
期刊: FASEB JOURNAL
影响因子: 4.8
作者: [Mizuno, Yuta, Chang, Hsi, Heike, Toshio]
通讯作者: Heike, Toshio
DOI: 10.1093/cvr/cvq189
发表时间: 2010-11-01
期刊: CARDIOVASCULAR RESEARCH
影响因子: 10.8
作者: [Kaichi, Shinji, Hasegawa, Koji, Heike, Toshio]
通讯作者: Heike, Toshio
7
    Establishing the research basis for innovative medical care of familial hemophagocytic lymphohistiocytosis.
    • 批准号:
      25670475
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2013
    • 负责人:
      HEIKE Toshio
    • 依托单位:
    Development of the next-generation medical treatment for muscularDystrophy
    • 批准号:
      23659520
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      HEIKE Toshio
    • 依托单位:
    Establishment of therapeutic strategy for degenerative muscular disease by embryonic stem mils
    • 批准号:
      18390298
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.36万
    • 财政年份:
      2006
    • 负责人:
      HEIKE Toshio
    • 依托单位:
    Establishment of therapeutic strategy for degenerative muscular disease by mouse or human somatic stem cells
    • 批准号:
      16390300
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.15万
    • 财政年份:
      2004
    • 负责人:
      HEIKE Toshio
    • 依托单位:
    海外基金