A disease spectrum induced by EB virus latent infections and the pathogenesis

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We have established a disease spectrum of EB virus (EBV)-associated T/NK-cell lymphoproliferative disorders (LPD), including hydroa vacciniforme (HV), hypersensitivity to mosquito bites (HMB) and chronic active EBV infections, and analysed their pathogeneses by cellular and molecular basis. In these disorders, we found that 1) in addition to the cutaneous and hematological symptoms, oculomucosal and gastrointestinal lesions were major complications, 2) EBV-infected cell types related to the development of these disorders were of γδT cells in HV, and of NK cells in HMB, 3) reactivation of EBV from the latent infection, or alterations of latency infection patterns were important to induce the clinical symptoms, 4) host cytotoxic T lymphocyte (CTL) ?mediated immune responses were induced against lytic-cycle infection-associated EBV antigens, 5) clinical significance of monitoring EBV DNA load, and 6) a possible therapeutic use of HDAC inhibitors.