Preferable biological milieu for the growth of viral epithelial neoplasms and its regulation

病毒上皮肿瘤生长及其调节的优选生物环境

• 批准号: 22659205
• 负责人: IWATSUKI Keiji
• 金额: $ 2.07万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659205/
• 关键词: ヒト乳頭腫ウイルス; 伝染性軟属腫; 樹状細胞; TSLP; 日光角化症; Bowen病; 伝染性軟属腫ウイルス; Th2; リモデリング; ウイルス; 乳頭腫; 腫瘍免疫; ケモカイン; 免疫微小環境; 接着因子

Dendritic cell(DC) subsets and regulatory mechanisms of host immune responses were studied in human papilloma virus(HPV)-and molluscum contagiosum virus(MCV)-associated warty lesions, Bowen disease, and various epithelial neoplasms. The depletion of Langerin+ DCs(LCs) was obvious in the non-inflammatory HPV-warts, MC, and HPV-Bowen. The lesional epidermis revealed diminished MIP-3αexpression and irregular distribution of E-cadherin. TSLP(thymic stromal lymphopoietin) was highly expressed in HPV-warts and solar keratosis, while a few MCV+ cells were positive for TSLP in MC. MCV-encoded immunoregulatory molecules such as MCV148 and MCV159 were expressed in MC. MIP-3αexpression is up-regulated in inflammatory warts, with the subsequent recruitment of various DC subsets and CD8+ cells. TSLP expression might be associated with immune suppression and Th2 type inflammation in HPV-warts, while MCV-encoded molecules possess a pivotal role in the persistence of MC.

树突状细胞（DC）亚群和宿主免疫反应的调节机制进行了研究，在人乳头瘤病毒（HPV）和传染性软疣病毒（MCV）相关的疣状病变，鲍文病，和各种上皮肿瘤。Langerin+ DC（LC）的消耗在非炎性HPV疣、MC和HPV-Bowen中是明显的。皮损表皮MIP-3α表达减弱，E-cadherin分布不规则。TSLP（Thymic stromal lymphopoietin）在HPV疣和日光性角化病中呈高表达，而在MC中少数MCV+细胞呈阳性。MCV编码的免疫调节分子如MCV 148和MCV 159在MC中表达。炎症性疣中MIP-3α表达上调，随后募集各种DC亚群和CD 8+细胞。TSLP的表达可能与HPV疣的免疫抑制和Th 2型炎症有关，而MCV编码的分子在MC的持续存在中具有关键作用。

项目成果

Clinical Endpoints and Response Criteria in Mycosis Fungoides and Sezary Syndrome : a Consensus Statement of the International Society for Cutaneous Lymphomas (ISCL), the United States Cutaneous Lymphoma Consortium (USCLC) and the Cutaneous Lymphoma Task

蕈样肉芽肿和塞扎里综合征的临床终点和缓解标准：国际皮肤淋巴瘤协会 (ISCL)、美国皮肤淋巴瘤联盟 (USCLC) 和皮肤淋巴瘤任务的共识声明

• 发表时间: 2011
• 期刊: Journal of Clinical Oncology
• 影响因子: 45.3
• 作者: Olsen E;et al
• 通讯作者: et al

Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands.

• DOI: 10.1038/jid.2011.259
• 发表时间: 2012-01
• 期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY
• 影响因子: 6.5
• 作者: Morizane, Shin;Yamasaki, Kenshi;Muehleisen, Beda;Kotol, Paul F.;Murakami, Masamoto;Aoyama, Yumi;Iwatsuki, Keiji;Hata, Tissa;Gallo, Richard L.
• 通讯作者: Gallo, Richard L.

Human herpesviruses and neoplasms

人类疱疹病毒和肿瘤

• 发表时间: 2011
• 作者: Shiba N;et al.;Iwatsuki K
• 通讯作者: Iwatsuki K

Adult T-cell leulemia/lymphoma. In Asian Skin and Skin Disease, edn. Eun HC, Kim SC, Lee WS

成人 T 细胞白血病/淋巴瘤。

• 发表时间: 2011
• 作者: Iwatsuki K. Histiocytoses. ed. Dummer R;Pittelkow MR;Iwatsuki K;Green A;Elwan NM;関正史,林泰秀;Iwatsuki K;橋本隆紀;星野諭子,林泰秀;Iwatsuki K
• 通讯作者: Iwatsuki K

ATM activation is indispensable in HSV, but ATM/ATR activation is not necessary in VZV for efficient replication

ATM 激活对于 HSV 是必不可少的，但 ATM/ATR 激活对于 VZV 的有效复制来说并不是必需的

• 发表时间: 2010
• 作者: Yamamoto T;Iwatsuki K;et al
• 通讯作者: et al