Inhibition of xeno-antigen reactive T cells and B cells by regulation of CD47-SIRP signaling

我们先前已经证明，CD47的种间不相容导致巨噬细胞在体外吞噬异种细胞。在这项研究中，我们证明了CD47的种间不亲和性通过间接途径而不是直接途径促进了异种反应性CD_4~+T细胞的体外反应。我们还利用体内模型证明了在异种移植细胞上对受体物种CD47的遗传诱导可以防止巨噬细胞介导的排斥反应。

We have previously proven that the interspecies incompatibility of CD47 results in phagocytosis of xenogeneic cells by macrophages in vitro. In this study, we demonstrated that interspecies incompatibility of CD47 contributed to the in vitro responses of xenoreactive CD4^+ T cell through the indirect pathway, but not the direct pathway. We also demonstrated that genetic induction of recipient species CD47 on xenograft cells could prevent macrophage-mediated rejection using an in vivo model.