Establishment of strategies to regulate antibody-mediated rejection on the basis of B cell differentiation biology
基于B细胞分化生物学调控抗体介导的排斥反应策略的建立
基本信息
- 批准号:23659614
- 负责人:
- 金额:$ 2.33万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Antibodies produced through the activation of T cell-dependent B-2 cells and independent B-1 cells are now appreciated as important mediators of acute and chronic rejection. It is important to suppress sufficiently both type of B cell activation for improvement of allograft survival. However, the sensitivity of B-1/B-2 cell differentiation to various immunosuppressants still remained to be elucidated. To address this issue, in the present study, we have established in vitro and in vivo B cell activation models, in which the differentiation to B-1a, B-1b, and B-2 cells can be induced. By use of those models, we have evaluate the sensitivity and specificity of various immunosuppressive drugs and anti-CD1d antibody newly developed by us to B cell activation.
通过激活T细胞依赖的B-2细胞和独立的B-1细胞产生的抗体现在被认为是急性和慢性排斥反应的重要介质。充分抑制这两种类型的B细胞活化对于改善同种异体移植物的存活率是很重要的。然而,B-1/B-2细胞分化对各种免疫抑制剂的敏感性仍有待阐明。为了解决这一问题,在本研究中,我们建立了体外和体内B细胞活化模型,可以诱导分化为B-1a、B-1b和B-2细胞。利用这些模型,我们评估了我们新开发的各种免疫抑制药物和抗cd1d抗体对B细胞活化的敏感性和特异性。
项目成果
期刊论文数量(44)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Assessment of the Sensitivity of B-1/B-2 Cell Differentiation to Various Immunosuppressants Using the In Vitro B Cell Activation Model.
使用体外 B 细胞激活模型评估 B-1/B-2 细胞分化对各种免疫抑制剂的敏感性。
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Yamashita M;Ohdan H
- 通讯作者:Ohdan H
ドナー特異的B細胞免疫応答の解析法
分析供体特异性 B 细胞免疫反应的方法
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:田澤宏文;伊禮俊充;五十嵐友香;田中友加;尾上隆司;井手健太郎;田原裕之;番匠谷将孝;小林剛;大下彰彦;天野尋暢;田代裕尊;大段秀樹;大段秀樹
- 通讯作者:大段秀樹
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OHDAN Hideki其他文献
OHDAN Hideki的其他文献
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{{ truncateString('OHDAN Hideki', 18)}}的其他基金
Development of a novel desensitization/immune-regulatory method by use of multi-potent suppressor B cells to induce immune-tolerance in allogeneic organ transplantation
开发一种新的脱敏/免疫调节方法,利用多能抑制B细胞诱导同种异体器官移植中的免疫耐受
- 批准号:
15H02555 - 财政年份:2015
- 资助金额:
$ 2.33万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of novel cell therapeutic strategy using unlicenced NK cells combined with molecular target medicine for liver cancer
利用未经许可的NK细胞联合分子靶向药物开发肝癌新型细胞治疗策略
- 批准号:
25670581 - 财政年份:2013
- 资助金额:
$ 2.33万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
The CD47-SIRPa signaling blockade accelerates macrophage phagocytic activity against cancer cells
CD47-SIRPa信号传导阻断加速巨噬细胞对癌细胞的吞噬活性
- 批准号:
23249064 - 财政年份:2011
- 资助金额:
$ 2.33万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Inhibition of xeno-antigen reactive T cells and B cells by regulation of CD47-SIRP signaling
通过调节 CD47-SIRP 信号传导抑制异种抗原反应性 T 细胞和 B 细胞
- 批准号:
20390344 - 财政年份:2008
- 资助金额:
$ 2.33万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Regulation of innate and adaptive immune responses in xenotransplantation by modulating CD47sirp α signaling
通过调节 CD47sirp α 信号调节异种移植中的先天性和适应性免疫反应
- 批准号:
18390348 - 财政年份:2006
- 资助金额:
$ 2.33万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Elucidation of mechanisms for macrophage-mediated xenograft refection and a novel approach to prevent macrophage-mediated xenograft rejection by gene introduction of human CD47 to xenogenic cells
阐明巨噬细胞介导的异种移植排斥的机制以及通过将人 CD47 基因引入异种细胞来预防巨噬细胞介导的异种移植排斥的新方法
- 批准号:
16591257 - 财政年份:2004
- 资助金额:
$ 2.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)