Alteration of delta-bilirubin concentration during biliary drainage and its relationships with plasma half-life of albumin and functional hepatocyte mass in patients with obstructive jaundice

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Plasma half-lives of delta and non-delta bilirubin fractions in patients with obstructive jaundice undergoing biliary drainages were 13.6 day and 2.4 day, respectively. Antipyrine and aminopyrine plasma clearances, which are indicators of liver microsomal function, were deteriorated by the obstructive jaundice but recovered rapidly after the biliary drainage. Other parameters of liver function showed wide range of alterations, i.e., from unaffected to moderate degree of deterioration, by the jaundice and also showed wide ranges of chronological changes during drainage. The half-lives of delta and non-delta bilirubin fractions showed close correlations with antipyrine and aminopyrine plasma clearances before the drainage and similar relationships were found with values of these clearances after the drainage. The episode of cholangitis during the drainage period and the absence of entero-hepatic circulation of the bile prolonged the half-lives of bilirubin fractions.