Identification and clinical application of colon cancer-specific gamma-secretase-targeting molecules

我们首次发现，γ分泌酶（GS）复合物通过GS依赖性和GS非依赖性机制调节结肠癌和胰腺癌细胞对紫杉烷的反应。GS依赖性途径不依赖于Notch信号传导。有趣的是，它强烈表明，GS复合物调节这些细胞的细胞周期进程中的GS-独立的方式。数据表明，GS复合物可能是一个新的治疗目标，克服耐药性紫杉烷在这些癌症。

We showed for the first time that gamma secretase (GS) complexes regulate the response of colon and pancreatic cancer cells to taxanes through GS-dependent and GS-independent mechanisms. GS-dependent pathway is independent of Notch signaling. Interestingly, it was strongly indicated that GS complexes regulate the cell cycle progression of these cells in a GS-independent manner. Data suggest that GS complexes could be a new therapeutic target for overcoming resistance to taxanes in these cancers.