Osteonecrosis of jaw bones induced by bisphosphonates : an approach to clarifying its underlying mechanism, prevention, and treatment

双磷酸盐引起的颌骨骨坏死：阐明其潜在机制、预防和治疗的方法

• 批准号: 20592318
• 负责人: YAMAGUCHI Kouji
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592318/
• 关键词: 口腔外科一般; 顎骨壊死; 骨吸収抑制; LPS

Osteonecrosis of the jawbone (ONJ) and its ensuing exposure induced by nitrogen-containing bisphosphonates (NBP) are taking much attention. Its underlying mechanism is not clear and there are no active methods for its prevention and treatment. Based on our findings in basic, animal experiments, we tried substitution of NBPs to etidronate (a non-NBP) for ONJ-patients with osteoporosis or tumor bone-metastasis, and observed a rapid removal of sequestra and a tendency of promoted curing. Etidronate, as a substitution drug for NBP, may be effective at treating or preventing NBP-induced ONJ or myelitis.

含氮双膦酸盐（NBP）引起的颌骨骨坏死（ONJ）及其后续暴露引起了广泛关注。其发病机制尚不清楚，目前尚无有效的防治方法。基于我们在基础动物实验中的发现，我们尝试用NBP替代依替膦酸盐（非NBP）治疗患有骨质疏松症或肿瘤骨转移的ONJ患者，并观察到死骨的快速清除和促进治愈的趋势。作为NBP的替代药物，依替膦酸盐可能有效地治疗或预防由NBP引起的ONJ或Mycobacteria。

项目成果

Juvenile Active Ossifying Fibroma of The Mandible Which Passed For Postoperative Five Years

青少年活动性下颌骨骨化纤维瘤术后五年

• 发表时间: 2010
• 作者: K.Yamaguchi;M.Numata;S.Sato;H.Kawamura
• 通讯作者: H.Kawamura

BP製剤関連顎骨壊死ポジションペーパーの解説とBRONJ治療経験について

BP制剂相关颌骨坏死意见书说明及BRONJ治疗经验

• 发表时间: 2010
• 作者: Piao J;Kamimura Y;Miyuki A;et al.;菅野勇樹,西條英人,井川和代,斉藤健太郎,瀬戸一郎,森良之,高戸毅;山口晃史
• 通讯作者: 山口晃史

パミドロネート(ビスホスホネート骨吸収抑制薬)が原因と考えられる下顎骨壊死の2例:発症機序と予防に関する考察

帕米膦酸盐（双膦酸盐骨吸收抑制剂）引起下颌骨坏死二例：发病机制思考及预防

• 发表时间: 2008
• 作者: Kouji Yamaguchi;Takefumi Oizumi,Yasuo Endo;Hiroshi Kawamura;山口晃史,大泉丈史,遠藤康男
• 通讯作者: 山口晃史,大泉丈史,遠藤康男

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Osteonecrosis of the jawbones in 2 osteoporosis patients treated with nitrogen-containing bisphosphonates : osteonecrosis reduction replacing NBP with non-NBP (etidronate) and rationale.

2例用含氮双膦酸盐治疗的骨质疏松症患者的颌骨骨坏死：用非NBP（依替磷酸盐）代替NBP减少骨坏死及其基本原理。

• 发表时间: 2010
• 期刊: J Oral Maxillofac Surg. 68
• 作者: Yamaguchi K;Oizumi T;Funayama H;Kawamura H;Sugawara S;Endo Y
• 通讯作者: Endo Y