Osteonecrosis of jaw bones induced by bisphosphonates : an approach to clarifying its underlying mechanism, prevention, and treatment

含氮双膦酸类化合物(NBP)引起的颌骨骨坏死(ONJ)及其暴露引起的骨质疏松症(ONJ)备受关注。其发病机制尚不清楚，目前尚无积极的防治方法。根据我们在基础动物实验中的发现，我们尝试用非NBP的NBPS替代依屈膦酸盐(一种非NBP)来治疗患有骨质疏松症或肿瘤骨转移的ONJ患者，观察到后遗症迅速消除，并有促进治愈的趋势。依替膦酸盐作为NBP的替代药物，可能在治疗或预防NBP所致的ONJ或脊髓炎方面有效。

Osteonecrosis of the jawbone (ONJ) and its ensuing exposure induced by nitrogen-containing bisphosphonates (NBP) are taking much attention. Its underlying mechanism is not clear and there are no active methods for its prevention and treatment. Based on our findings in basic, animal experiments, we tried substitution of NBPs to etidronate (a non-NBP) for ONJ-patients with osteoporosis or tumor bone-metastasis, and observed a rapid removal of sequestra and a tendency of promoted curing. Etidronate, as a substitution drug for NBP, may be effective at treating or preventing NBP-induced ONJ or myelitis.