Osteonecrosis of jaw bones induced by bisphosphonates : an approach to clarifying its underlying mechanism, prevention, and treatment
Osteonecrosis of jaw bones induced by bisphosphonates : an approach to clarifying its underlying mechanism, prevention, and treatment
批准号:
20592318
负责人:
YAMAGUCHI Kouji
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
含氮双膦酸盐(NBP)引起的颌骨骨坏死(ONJ)及其后续暴露引起了广泛关注。其发病机制尚不清楚,目前尚无有效的防治方法。基于我们在基础动物实验中的发现,我们尝试用NBP替代依替膦酸盐(非NBP)治疗患有骨质疏松症或肿瘤骨转移的ONJ患者,并观察到死骨的快速清除和促进治愈的趋势。作为NBP的替代药物,依替膦酸盐可能有效地治疗或预防由NBP引起的ONJ或Mycobacteria。
英文摘要
Osteonecrosis of the jawbone (ONJ) and its ensuing exposure induced by nitrogen-containing bisphosphonates (NBP) are taking much attention. Its underlying mechanism is not clear and there are no active methods for its prevention and treatment. Based on our findings in basic, animal experiments, we tried substitution of NBPs to etidronate (a non-NBP) for ONJ-patients with osteoporosis or tumor bone-metastasis, and observed a rapid removal of sequestra and a tendency of promoted curing. Etidronate, as a substitution drug for NBP, may be effective at treating or preventing NBP-induced ONJ or myelitis.
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发表时间:
2010
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2010
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发表时间:
2008
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[Kouji Yamaguchi, Takefumi Oizumi,Yasuo Endo, Hiroshi Kawamura, 山口晃史,大泉丈史,遠藤康男]
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山口晃史,大泉丈史,遠藤康男
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[]
通讯作者:
Osteonecrosis of the jawbones in 2 osteoporosis patients treated with nitrogen-containing bisphosphonates : osteonecrosis reduction replacing NBP with non-NBP (etidronate) and rationale.
2例用含氮双膦酸盐治疗的骨质疏松症患者的颌骨骨坏死:用非NBP(依替磷酸盐)代替NBP减少骨坏死及其基本原理。
DOI:
--
发表时间:
2010
期刊:
J Oral Maxillofac Surg. 68
影响因子:
--
作者:
[Yamaguchi K, Oizumi T, Funayama H, Kawamura H, Sugawara S, Endo Y]
通讯作者:
Endo Y
共 39 条
Identification and clinical application of colon cancer-specific gamma-secretase-targeting molecules
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批准号:20390361
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.65万
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财政年份:2008
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负责人:YAMAGUCHI Kouji
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依托单位:
Development of pancreatic cancer therapy and prevention using morphogen as a target signaling pathway
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批准号:17591414
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:YAMAGUCHI Kouji
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依托单位:
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