Molecular analysis of lung adenocarcinomas that do not have mutations in the EGFR pathway and development of therapeutic strategies against them

EGFR 通路无突变肺腺癌的分子分析及其治疗策略的开发

• 批准号: 20390376
• 负责人: MITSUDOMI Tetsuya
• 金额: $ 12.23万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390376/
• 关键词: 呼吸器外科学; 分子標的治療; 個別化医療; 肺癌; EGFR経路; HER2; 腺癌; 個別化治療; 分子分類

EGFR tyrosine kinase inhibitor confers often dramatic response in lung cancer harboring EGFR mutation. However, virtually all the tumors acquire resistance. For large fraction of lung cancer, a efficacious therapeutic target is not known. In this study, we confirmed the HER2 mutation or MET amplification could be the therapeutic target although their incidences were low. Furthermore, we found a reciprocal relationship between T790M secondary mutation of the EGFR gene and MET amplification in acquire resistance.

EGFR 酪氨酸激酶抑制剂通常对携带 EGFR 突变的肺癌产生显着的反应。然而，几乎所有肿瘤都会产生耐药性。对于大部分肺癌，有效的治疗靶点尚不清楚。在这项研究中，我们证实 HER2 突变或 MET 扩增可能是治疗靶点，尽管它们的发生率较低。此外，我们发现 EGFR 基因的 T790M 二次突变与获得性耐药中的 MET 扩增之间存在相互关系。

项目成果

EGFR阻害剤耐性のメカニズム

EGFR 抑制剂耐药机制

• 发表时间: 2008
• 期刊: Annual Review呼吸器2008.東京:中外医学社
• 作者: 高坂貴行;小野里良一;光冨徹哉
• 通讯作者: 光冨徹哉

Reciprocal and Complementary Role of MET Amplification and EGFR T790M Mutation in Acquired Resistance to Kinase Inhibitors in Lung Cancer

• DOI: 10.1158/1078-0432.ccr-10-1371
• 发表时间: 2010-11-15
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Suda, Kenichi;Murakami, Isao;Mitsudomi, Tetsuya
• 通讯作者: Mitsudomi, Tetsuya

Clinicopathologic features of eraly stage lung cancer with EML4-ALK tranlocation

EML4-ALK易位早期肺癌的临床病理特征

• 发表时间: 2010
• 作者: Mitsudomi T;Suda K;Tomozawa K;Yatabe Y
• 通讯作者: Yatabe Y

EGFR遺伝子変異L858Rと Exon 19欠失変異のバリエーションの検討

EGFR基因突变L858R和外显子19缺失突变的变异检查

• 发表时间: 2008
• 作者: 須田健一;小野里良一;高坂貴行;谷田部恭;光冨徹哉
• 通讯作者: 光冨徹哉

Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor-Activating Mutations

• DOI: 10.1158/0008-5472.can-08-1643
• 发表时间: 2008-11-15
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Yano, Seiji;Wang, Wei;Sone, Saburo
• 通讯作者: Sone, Saburo