Exploration of possible catabolic factors in osteoarthritis through the analysis of large numbers of human samples.

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In this project, we have obtained synovial and cartilage tissues and synovial fluid samples from a large number of knee OA patients at various disease severities, and conducted a series of gene expression and protein analyses. Through the analyses, we have constructed a data base about human OA tissues and synovial fluid, which we found highly useful in exploration of possible catabolic factors for cartilage in the disease. Utilizing this data base, we were able to identify several possible catabolic factors in OA. Through a series of analyses with the data, we have identified a possible mechanism for synovial changes in OA. Validation of the significance of these factors in the disease is a future problem which should be answered by subsequent studies.