Strategic research for the identification of novel osteogenic small compounds and their application to bone regeneration

本研究旨在通过鉴定新型成骨小分子化合物，开发有效的药物递送系统，并评估此类化合物在骨缺损模型中的骨再生活性，开发基于小分子化合物的骨再生医学的基础技术。在这里，我们确定光甘草黄酮和淫羊藿苷为成骨小化合物。此外，我们建立了磷酸钙为基础的系统，这些化合物的控制释放，并验证了其在动物模型中的骨再生活性。

This study aims to develop fundamental technologies for small compound-based bone regenerative medicine through the identification of novel osteogenic small compounds, the development of effective drug delivery system, and the assessment of bone regeneration activities of such compounds in bone defect models. Here we identified glabrisoflavone and icariin as osteogenic small compounds. In addition, we established calcium phosphate-based systems for the controlled release of those compounds, and verified their bone regeneration activities in animal models.