Development of the fluorescence augmented reality navigation surgery to visualize the carcinoma tissue and sentinel lymph node

在癌症相关手术中，虽然三维确定原发肿瘤的浸润范围和受累淋巴结的部位非常重要，但易于识别的前哨淋巴结将改善治疗效果。如果肿瘤存在位置的信息能够被置于患者图像之上，以作为外科医生的新眼睛显示在真实的实时三维显示器上，则可能显著提高图像引导外科手术的可操作性。本研究通过引入最新的增强现实技术、荧光成像方法和图像传感技术，开发了在真实的空间中对宏观上不清楚的浸润范围和转移灶进行三维可视化的基础技术。建立了使用具有用于在真实的空间中进行位置测量的高精度CCD相机的机器视觉系统来指定用于空间位置关系的精确匹配的空间坐标的系统。

In cancer-related surgeries, while it is extremely important to three-dimensionally ascertain the invasion extent of primary tumor and the parts of involved lymph nodes, the easy identification of sentinel lymph nodes would improve the treatment results. If the information on the location where a tumor exists can be laid on top of a patient's image to be displayed on a real time three-dimensional display as a surgeon's new eyes, it is likely that the operability of image-guided surgery is improved markedly. In the study, we developed the fundamental technology to visualize the macroscopically unclear invasion extent and metastatic focus three-dimensionally in real space by introducing the newest augmented reality technology, fluorescence imaging method, and picture sensing technology. The system which specifies the space coordinates for accurate matching of a spatial positional relationship using the machine vision system with a high precision CCD camera for position measurement in real space was established.