The genomic epidemiology and immunological cohort study on amoebiasis in South Asia

我们对孟加拉国阿米巴病进行了基因组流行病学和免疫学队列研究，发现莫什科夫斯基内阿米巴在孟加拉国流行。莫氏内阿米巴在形态学上与致病性溶组织内阿米巴和非致病性异内阿米巴难以区分。由于e.m oshkovskii一直被认为是一种非致病性或自由生活的变形虫，因此阐明其致病性的研究很少。因此，我们开展了这项研究，以澄清莫氏大肠杆菌的致病性。在孟加拉国检查了腹泻发作中每一种内阿米巴原虫的流行情况，发现几例仅对莫什科夫斯基肠杆菌呈阳性，但对其他可能引起腹泻的微生物呈阴性。发现莫什科夫斯基大肠杆菌对小鼠具有致病性，并与孟加拉国儿童的腹泻发作密切相关。因此，重新评估莫什科夫斯基大肠杆菌的致病性具有重要意义。

We have carried out the genomic epidemiology and immunological cohort study on amoebiasis in Bangladesh and found that Entamoeba moshkovskii was prevalent in Bangladesh. E. moshkovskii is morphologically indistinguishable from pathogenic E. histolytica and non-pathogenic Entamoeba dispar. As E. moshkovskii has been considered to be a non-pathogenic or a free living amoeba, there are few studies to elucidate the pathogenicity of it. Thus, we carried out the study to clarify the pathogenicity of E. moshkovskii. The prevalence of each Entamoeba spp. in diarrheal episode was examined in Bangladesh and several cases that were positive only for E. moshkovskii but negative for other conceivable diarrhea-causative microbes were found. E. moshkovskii was found to be pathogenic to mice and to well associate with diarrheal episode in Bangladeshi children. Therefore it is important to re-estimate the pathogenicity of E. moshkovskii.