The genomic epidemiology and immunological cohort study on amoebiasis in South Asia

南亚阿米巴病基因组流行病学和免疫学队列研究

• 批准号: 23406009
• 负责人: HAMANO Shinjiro
• 金额: $ 12.23万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23406009/
• 关键词: 赤痢アメーバ; 新生児; 乳児; コホート研究; Entamoeba histolytica; Entamoeba moshkovskii; 南アジア; バングラディシュ; バングラデシュ; 国際研究者交流; 感染症; 下痢症; 赤痢アメーバ症; ゲノム疫学

In Mirpur, Dhaka, Bangladesh, natural exposure to Entamoeba spp. in infancy was prospectively observed. Approxymately, 80% of children had been infected with Entamoeba histolytica by age two years, with around 20% having suffered from E. histolytica. Furthermore, newly acquired E. moshkovskii infection was associated with diarrhea. Genetic analysis revealed that E. moshkovskii isolates infecting children were genetically heterogeneous, as evidenced by PCR typing of tRNA locus R-R. It will be important in future studies of the potential pathogenicity of E. moshkovskii to take into account this heterogeneity, as for the case of E. histolytica, not every genotype is equally capable of causing disease.

在孟加拉国达卡米尔普尔，前瞻性地观察了婴儿期自然暴露于内阿米巴原虫的情况。大约80%的儿童在两岁时感染了溶组织内阿米巴原虫，其中约20%患有溶组织内阿米巴原虫。此外，新获得的莫什科夫斯基肠杆菌感染与腹泻有关。遗传分析表明，感染儿童的莫什科夫斯基大肠杆菌具有遗传异质性，tRNA位点R-R的PCR分型证实了这一点。考虑到这种异质性在未来研究莫什科夫斯基大肠杆菌的潜在致病性中将是很重要的，就溶组织大肠杆菌而言，并非每种基因型都具有同样的致病能力。

项目成果

Entamoeba moshkovskii is pathogenic and causes intestinal symptoms.

莫什科夫斯基内阿米巴具有致病性，会引起肠道症状。

• 发表时间: 2011
• 作者: Chikako Shimokawa;Mamum Kabir;Mami Taniuchi;Dinesh Mondal;Seiki Kobayashi;Ibne Karim M. Ali;Masachika Senba;Eric Hoput;Haque Rashidul;William A. Petri Jr.;Shinjiro Hamano:
• 通讯作者: Shinjiro Hamano:

Intestinal inflammatory mediated clearance of Entamoeba moshkovskii isdependent on IFN-γ

莫什科夫斯基内阿米巴肠道炎症介导的清除依赖于 IFN-γ

• 发表时间: 2013
• 作者: Gaowa;Yoshikawa;Y.;Ohashi;N.;Wu;D.;Kawamori;F.;Ikegaya;A.;Watanabe;T.;Saitoh;K.;Takechi;D.;Murakami;Y.;Shichi;D.;Aso;K.;and Ando;S.;Shinjiro Hamano and Chikako Shimokawa
• 通讯作者: Shinjiro Hamano and Chikako Shimokawa

Intestinal inflammatory mediated clearance of Entamoeba moshkovskii is dependent on IFN-γ. Forum Cheju 16

莫什科夫斯基内阿米巴的肠道炎症介导的清除依赖于 IFN-γ Forum Cheju 16。

• 发表时间: 2013
• 作者: Takano;I.;Fujita;H.;Kadosaka;T.;Takahashi;M.;Yamauchi;T. Ishiguro;F.;Takada;N.;Yano;Y.;Oikawa;Y.;Honda;T.;Gokuden;M.;Tsunoda;T.;Tsurumi;M.;Ando;S.;Andoh;M.;Sato;K.;Kawabata;H.;Shinjiro Hamano and Chikako Shimokawa
• 通讯作者: Shinjiro Hamano and Chikako Shimokawa

IFN-・ is necessary for clearance of pathogenic amoebae from the intestine of mice

IFN-·对于清除小鼠肠道中的致病性阿米巴原虫是必需的

• 发表时间: 2012
• 作者: Chikako Shimokawa;Shinjiro Hamano
• 通讯作者: Shinjiro Hamano

アメーバ症, 今日の診断指針第7版

阿米巴病，今日诊断指南第七版

• 发表时间: 2014
• 作者: Gaowa;Wuritu;Wu D;Yoshikawa Y;Ohashi N;Kawamori1 F;Sugiyama K;Ohtake M;Ohashi M;Yamamoto S;Kitano T;Takada N;and Kawabata H;Shinjiro Hamano and Chikako Shimokawa;濱野真二郎
• 通讯作者: 濱野真二郎