Activation of mesocorticolimbic dopaminergic system by environmental enrichment and trophic factor expression
Activation of mesocorticolimbic dopaminergic system by environmental enrichment and trophic factor expression
批准号:
20500289
负责人:
HIDA Hideki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
To investigate the function of mesocorticolimbic dopaminergic (DAergic) system in developing rats grown in environmental enrichment (EE), gene expressions of DA receptors and cocaine- and amphetamine-related transcript(CART) and analysis of emotional behavior were carried out. It revealed that expression of DA receptor type IV and CART in prefrontal cortex and amygdala was altered by EE, and also found out that emotional behavior such as anxiety-behavior was reduced in rats grown in EE.
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Enhanced neurogenesis from neural progenitor cells with G1/S-phase cell cycle arrest is mediated by transforming growth factor b1.
转化生长因子 b1 介导 G1/S 期细胞周期停滞的神经祖细胞的神经发生增强。
DOI:
--
发表时间:
2008
期刊:
Eur J Neurosci 28(6)
影响因子:
--
作者:
[Misumi S, Kim TS, Jung CG, Masuda T, Urakawa S, Iosbe Y, Furuyama F, Nishino H, Hida H]
通讯作者:
Hida H
Pretreatment with low doses of erythropoietin ameliorate brain damage in periventricular leukomalacia model rats by targeting late oligodendrocyte progenitors : A rat model.
低剂量促红细胞生成素预处理通过靶向晚期少突胶质细胞祖细胞改善脑室周围白质软化模型大鼠的脑损伤:大鼠模型。
DOI:
--
发表时间:
2008
期刊:
Neonatology 94
影响因子:
--
作者:
[Mizuno K, Hida H, Masuda T, Nishino H, Togari H.]
通讯作者:
Togari H.
Efficient induction of oligodendrocytes from mouse ES cells : immunocytochemical and electrophysiological evidences
有效诱导小鼠 ES 细胞少突胶质细胞:免疫细胞化学和电生理学证据
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Fujita M, Misumi S, Hida H, et al]
通讯作者:
et al
Increase in dopaminergic neurons from mouse embrypnic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-lalpha
缺氧诱导因子-lα介导小鼠胚胎干细胞源性神经祖细胞/干细胞多巴胺能神经元的增加
DOI:
--
发表时间:
2008
期刊:
Journal of Neuroscience Reserch 86(11)
影响因子:
--
作者:
[Kim TS, Hida H, et al]
通讯作者:
et al
DOI:
10.1002/jnr.22566
发表时间:
2011-03-01
期刊:
JOURNAL OF NEUROSCIENCE RESEARCH
影响因子:
4.2
作者:
[Ishida, Akimasa, Ueda, Yoshitomo, Hida, Hideki]
通讯作者:
Hida, Hideki
共 16 条
Reconstruction of disturbed brain function with neural stem cells from the investigation of the mechanism and induction to neuronal differentiation by trophic factor
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批准号:16500203
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:HIDA Hideki
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依托单位:
海外基金