Activation of mesocorticolimbic dopaminergic system by environmental enrichment and trophic factor expression

通过环境富集和营养因子表达激活中皮质边缘多巴胺能系统

• 批准号: 20500289
• 负责人: HIDA Hideki
• 金额: $ 2.91万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500289/
• 关键词: 豊かな環境飼育; 脳内ドパミン神経系; ラット; 情動行動; ドパミン受容体; 側坐核; 内側前頭野; real-time PCR; 外部環境の変化; 注意欠陥多動性障害; モデルラット; 中脳皮質辺縁系; オープンフィールド試験; CART; D4R; ドパミン代謝; ADHD; SHRラット; オープンフィールド; RT-RCR; pleiotrophin; ドパミン; 辺縁系; 大脳皮質; 受容体; 栄養因子; 認知; 飼育環境

To investigate the function of mesocorticolimbic dopaminergic (DAergic) system in developing rats grown in environmental enrichment (EE), gene expressions of DA receptors and cocaine- and amphetamine-related transcript(CART) and analysis of emotional behavior were carried out. It revealed that expression of DA receptor type IV and CART in prefrontal cortex and amygdala was altered by EE, and also found out that emotional behavior such as anxiety-behavior was reduced in rats grown in EE.

为探讨中皮质边缘多巴胺能（DA能）系统在丰富环境（EE）发育大鼠中的功能，本研究通过对DA能受体、可卡因和苯丙胺相关转录本（CART）基因表达及情绪行为的分析，探讨DA能系统在EE发育中的作用。结果表明，EE改变了前额叶皮层和杏仁核中DA受体IV型和CART的表达，并且还发现在EE中生长的大鼠中情绪行为如焦虑行为减少。

项目成果

Enhanced neurogenesis from neural progenitor cells with G1/S-phase cell cycle arrest is mediated by transforming growth factor b1.

转化生长因子 b1 介导 G1/S 期细胞周期停滞的神经祖细胞的神经发生增强。

• 发表时间: 2008
• 期刊: Eur J Neurosci 28(6)
• 作者: Misumi S;Kim TS;Jung CG;Masuda T;Urakawa S;Iosbe Y;Furuyama F;Nishino H;Hida H
• 通讯作者: Hida H

Pretreatment with low doses of erythropoietin ameliorate brain damage in periventricular leukomalacia model rats by targeting late oligodendrocyte progenitors : A rat model.

低剂量促红细胞生成素预处理通过靶向晚期少突胶质细胞祖细胞改善脑室周围白质软化模型大鼠的脑损伤：大鼠模型。

• 发表时间: 2008
• 期刊: Neonatology 94
• 作者: Mizuno K;Hida H;Masuda T;Nishino H;Togari H.
• 通讯作者: Togari H.

Efficient induction of oligodendrocytes from mouse ES cells : immunocytochemical and electrophysiological evidences

有效诱导小鼠 ES 细胞少突胶质细胞：免疫细胞化学和电生理学证据

• 发表时间: 2009
• 作者: Fujita M;Misumi S;Hida H;et al
• 通讯作者: et al

Increase in dopaminergic neurons from mouse embrypnic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-lalpha

缺氧诱导因子-lα介导小鼠胚胎干细胞源性神经祖细胞/干细胞多巴胺能神经元的增加

• 发表时间: 2008
• 期刊: Journal of Neuroscience Reserch 86(11)
• 作者: Kim TS;Hida H;et al
• 通讯作者: et al

Minor Neuronal Damage and Recovered Cellular Proliferation in the Hippocampus After Continuous Unilateral Forelimb Restraint in Normal Rats

• DOI: 10.1002/jnr.22566
• 发表时间: 2011-03-01
• 期刊: JOURNAL OF NEUROSCIENCE RESEARCH
• 影响因子: 4.2
• 作者: Ishida, Akimasa;Ueda, Yoshitomo;Hida, Hideki
• 通讯作者: Hida, Hideki