Analysis of the role of IP_3 receptor in higher brain function

IP_3受体在高级脑功能中的作用分析

• 批准号: 20500301
• 负责人: HISATSUNE Chihiro
• 金额: $ 2.91万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500301/
• 关键词: calcium; IP_3R; brain; dystonia; conditional; knockout; mice; イノシトール3リン酸; 脳; 運動; IP3 receptor; Inositol trisphosphate receptor; knockout mice; Ca^<2+> signal; Brain

Inositol trisphosphate receptor (IP_3R1) is one of the important Ca^<2+> channels that release Ca^<2+> from the endoplasmic reticulum (ER). There are three subtypes of IP_3R so far, and IP_3R1 is a major subtype in the central nerves systems. In this study, we constructed several brain-specific IP_3R1 conditional IP_3R1 mice and analyzed the role of IP_3R1 in the higher brain function.

三磷酸肌醇受体（IP_3R1）是内质网释放Ca^2+的重要通道之一。IP_3R有三种亚型，其中IP_3R1是中枢神经系统中的主要亚型。本研究构建了脑特异性IP_3R1条件性IP_3R1小鼠，并分析了IP_3R1在脑高级功能中的作用。

项目成果

G-protein-coupled Receptor Kinase-interacting Proteins Inhibit Apoptosis by Inositol 1,4,5-Triphosphate Receptor-mediated Ca2+ Signal Regulation*

• DOI: 10.1074/jbc.m109.041509
• 发表时间: 2009-08
• 期刊: The Journal of Biological Chemistry
• 作者: Songbai Zhang;C. Hisatsune;T. Matsu-ura;K. Mikoshiba

Handbook of Neurochemistry and Molecular Neurobiology(Chapter25 : Signal molecules and Calcium : IP_3 receptor and Ca^<2+> signaling)

神经化学和分子神经生物学手册（第25章：信号分子和钙：IP_3受体和Ca^<2>信号传导）

• 发表时间: 2009
• 作者: Chihiro Hisatsune;Katsuhiko Mikoshiba
• 通讯作者: Katsuhiko Mikoshiba

Isolation of inositol 1, 4, 5-trisphosphate receptor-associating proteins and selective knockdown using RNA interference

使用 RNA 干扰分离肌醇 1,4,5-三磷酸受体相关蛋白并选择性敲低

• DOI: 10.1007/978-1-60327-175-2_9
• 发表时间: 2010
• 期刊: Methods Mol Biol
• 作者: Mizutani A;Kawaai K;Hisatsune C;Ando H;Michikawa T;Mikoshiba K
• 通讯作者: Mikoshiba K

Mechanism of ER Stress-Induced Brain Damage by IP3 Receptor

• DOI: 10.1016/j.neuron.2010.11.010
• 发表时间: 2010-12-09
• 期刊: NEURON
• 影响因子: 16.2
• 作者: Higo, Takayasu;Hamada, Kozo;Mikoshiba, Katsuhiko
• 通讯作者: Mikoshiba, Katsuhiko

80K-H Interacts with Inositol 1,4,5-Trisphosphate (IP3) Receptors and Regulates IP3-induced Calcium Release Activity*

• DOI: 10.1074/jbc.m805828200
• 发表时间: 2009-01
• 期刊: Journal of Biological Chemistry
• 影响因子: 4.8
• 作者: Katsuhiro Kawaai;C. Hisatsune;Y. Kuroda;A. Mizutani;T. Tashiro;K. Mikoshiba