L-plastin ; the possibility as a surrogate marker of polyglutamine diseases.

L-塑性蛋白；

• 批准号: 20500322
• 负责人: TOYOSHIMA Yasuko
• 金额: $ 2.5万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500322/
• 关键词: ポリグルタミン病; L-プラスチン; 治療予測マーカー; 脳神経疾患病理学; 脳神経疾患; 病理学

L-plastin is a protein involved in actin filament organization and endocytotic processes. We found that the expression of L-plastin increased in the brains of polyglutamine diseases. We examined the relations about the L-plastin and polyglutamine. L-plastin was shown to come to have much expression in the progress of several weeks in vitro. It is thought that L-plastin may be related with a phenomenon to need time before polyglutamine disease develops.

L-塑蛋白是一种参与肌动蛋白丝组织和内吞过程的蛋白质。我们发现多聚谷氨酰胺疾病患者大脑中 L-plastin 的表达增加。我们研究了 L-plastin 和聚谷氨酰胺的关系。 L-塑蛋白在体外几周的过程中显示出大量表达。人们认为，L-塑蛋白可能与多聚谷氨酰胺疾病发生之前需要时间的现象有关。

项目成果

Spinocerebellar Ataxia Type 17 (SCA17).

脊髓小脑共济失调 17 型 (SCA17)。

• 发表时间: 2008
• 期刊: GeneReviews at GeneTests
• 作者: Toyoshima Y;Onodera O;Yamada M;et al.
• 通讯作者: et al.

Sporadic amyotrophic lateral sclerosis : Widespread multisysytem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator.

散发性肌萎缩侧索硬化症：长期依赖呼吸器生存的患者出现广泛的多系统变性，伴有 TDP-43 病理学。

• 发表时间: 2009
• 期刊: Neuropathology 29
• 作者: Nishihira Y;Tan CF;Toyoshima Y;et al.
• 通讯作者: et al.

Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study

• DOI: 10.1002/mds.22583
• 发表时间: 2009-07-15
• 期刊: MOVEMENT DISORDERS
• 影响因子: 8.6
• 作者: Kanazawa, Masato;Shimohata, Takayoshi;Nishizawa, Masatoyo
• 通讯作者: Nishizawa, Masatoyo

Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease

• DOI: 10.1007/s00401-009-0552-x
• 发表时间: 2009-10-01
• 期刊: ACTA NEUROPATHOLOGICA
• 影响因子: 12.7
• 作者: Tan, Chun-Feng;Yamada, Mitsunori;Takahashi, Hitoshi
• 通讯作者: Takahashi, Hitoshi

Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death

• DOI: 10.1093/brain/awp110
• 发表时间: 2009-07-01
• 期刊: BRAIN
• 影响因子: 14.5
• 作者: Tada, Mari;Kakita, Akiyoshi;Takahashi, Hitoshi
• 通讯作者: Takahashi, Hitoshi