L-plastin ; the possibility as a surrogate marker of polyglutamine diseases.

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L-plastin is a protein involved in actin filament organization and endocytotic processes. We found that the expression of L-plastin increased in the brains of polyglutamine diseases. We examined the relations about the L-plastin and polyglutamine. L-plastin was shown to come to have much expression in the progress of several weeks in vitro. It is thought that L-plastin may be related with a phenomenon to need time before polyglutamine disease develops.