Analysis of the role of a protein tyrosine phosphatase in regulation of neuronal functions
Analysis of the role of a protein tyrosine phosphatase in regulation of neuronal functions
批准号:
20500332
负责人:
OHNISHI Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
To investigate the functional roles of cytoplasmic protein tyrosine phosphatase Shp2 in the brain, I have generated adult forebrain specific Shp2 conditional KO (cKO) mice by the use of Cre-LoxP system. The effect of Shp2 ablation on the brain functions is now being examined in the cKO mice by the use of several behavioral tests. In this project, I have also investigated a signaling mechanism of tyrosine phosphorylation of SIRPa, which is a major binding protein of Shp2 in the brain, and found that cold-stress induced tyrosine phosphorylation of SIRPa in the brain.
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腸管におけるSHPS-1発現と腸管免疫制御
SHPS-1在肠道中的表达与肠道免疫调节
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[金澤義丈, 齋藤泰之, ヤナ, スプリアトナ, 村田陽二, 岡澤秀樹, 大西浩史, 下瀬川透, 的崎尚]
通讯作者:
的崎尚
Defective development of dendritic cells in SHPS-1 mutant mice
SHPS-1突变小鼠树突状细胞发育缺陷
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Saito, Y. et. al.]
通讯作者:
Y. et. al.
Functions and molecular mechanisms of the CD47-SIRPa signaling pathway.
CD47-SIRPa信号通路的功能和分子机制。
DOI:
--
发表时间:
2009
期刊:
Trends Cell Biol. Vol.19
影响因子:
--
作者:
[Matozaki T., Murata Y., Okazawa H., Ohnishi H.]
通讯作者:
Ohnishi H.
腸微絨毛異的な発現を示す受容体型チロシンホスファターゼSAP-1とIL-10による炎症性腸疾患の制御
肠道微绒毛中差异表达的受体酪氨酸磷酸酶 SAP-1 和 IL-10 控制炎症性肠病
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[小谷武徳, 他]
通讯作者:
他
CD47-SIRPα系による樹状細胞の恒常性の制御
CD47-SIRPα系统对树突状细胞稳态的调节
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[齊藤泰之, 他]
通讯作者:
他
共 60 条
Analysis of the signaling mechanisms that regulates brain stress responses through protein tyrosine phosphorylation
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批准号:23500437
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2011
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负责人:OHNISHI Hiroshi
-
依托单位:
The role of visceral adipose tissue CD8+ T cells in obese murine asthma model
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批准号:23591120
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2011
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负责人:OHNISHI Hiroshi
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依托单位:
Analysis of protein tyrosine phosphorylation signal, which regulates synaptic function.
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批准号:16500236
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:OHNISHI Hiroshi
-
依托单位:
Mathematical Modeling of the Marxian Economics Based on Neoclassical Growth Model
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批准号:16530115
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:2004
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负责人:OHNISHI Hiroshi
-
依托单位:
海外基金