Protective effects of molecular hydrogen on a stress-induced brain dysfunction

氢分子对应激引起的脑功能障碍的保护作用

• 批准号: 20500345
• 负责人: OHSAWA Ikuroh
• 金额: $ 2.83万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500345/
• 关键词: 精神; 神経疾患の病態と治療; モデル動物; 酸化ストレス; 認知・記憶障害

We investigated the effect of molecular hydrogen on a stress-induced brain dysfunction including cognitive and memory impairment, depression, and anxiety. We have recently reported that molecular hydrogen reduces oxidative stress and can penetrate the blood-brain barrier to protect neurons. Oxidative stress is widely accepted as a contributor to neuronal vulnerability and prevents hippocampal neurogenesis, which may be involved in cognitive function. The main results in this study have been published in Neuropsycopharmacology. Immobilization stress was given to mice 10 hours per day for 6 weeks. Water containing high concentration of hydrogen molecule (hydrogen water) was available ad libitum. We examined learning and memory ability using the passive avoidance test, novel recognition test and Morris water maze, and found that hydrogen water improved a stress-induced decline of cognitive function. Hydrogen water also restored the neurogenesis declined by restraint stress and reduced oxidative stress in the brain. Furthermore, we made depression-model mice with a combination of mild stress and did not find any effect of hydrogen water on this model, whereas hydrogen water restored a decline of neurogenesis. Precise molecular mechanisms concerning the effect of molecular hydrogen on neuronal cells is under investigation.

我们研究了分子氢在应激诱导的脑功能障碍中的作用，包括认知和记忆障碍、抑郁和焦虑。我们最近报道，分子氢可以降低氧化应激，并可以穿透血脑屏障来保护神经元。氧化应激被广泛认为是神经元脆弱性的一个因素，并阻止海马神经发生，这可能与认知功能有关。这项研究的主要结果已发表在《神经心理药理学》上。每天给予小鼠10h的束缚应激，连续6周。含有高浓度氢分子的水(氢水)可随意使用。我们使用被动回避测试、新颖再认测试和Morris水迷宫测试了学习和记忆能力，发现氢水改善了应激诱导的认知功能下降。氢水还恢复了因束缚压力而下降的神经再生，并减少了大脑中的氧化应激。此外，我们制作了轻度应激组合的抑郁症模型小鼠，没有发现氢水对该模型的任何影响，而氢水恢复了神经发生的下降。关于分子氢对神经细胞影响的确切分子机制正在研究中。

项目成果

Cytoprotective role of mitochondrial amyloid β peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde.

线粒体淀粉样β肽结合乙醇脱氢酶对细胞毒性醛的细胞保护作用。

• 发表时间: 2009
• 期刊: Neurobiol. Aging. 30
• 作者: Murakami;Y.;Ohsawa;I.;Kasahara;T.;Ohta;S.
• 通讯作者: S.

Consumption of hydrogen water prevents the age-dependent impairment in learning and memorv tasks in AD model mice

饮用氢水可以预防 AD 模型小鼠年龄依赖性的学习和记忆任务障碍

• 发表时间: 2010
• 作者: Ohsawa;I.
• 通讯作者: I.

Hydrogen acts as a therapeutic antioxidant in the brain ischemia and restores learning- and memory-deficits declined by physical restraint stress.

氢在脑缺血中充当治疗性抗氧化剂，并恢复因身体束缚压力而下降的学习和记忆缺陷。

• 发表时间: 2008
• 作者: 大澤;郁朗;大澤郁朗
• 通讯作者: 大澤郁朗

Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory

• DOI: 10.1016/j.bbr.2008.12.038
• 发表时间: 2009-06-08
• 期刊: BEHAVIOURAL BRAIN RESEARCH
• 影响因子: 2.7
• 作者: Nakajima, Sanae;Ohsawa, Ikuroh;Mikami, Toshio
• 通讯作者: Mikami, Toshio

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

• DOI: 10.1038/npp.2008.95
• 发表时间: 2009-01-01
• 期刊: NEUROPSYCHOPHARMACOLOGY
• 影响因子: 7.6
• 作者: Nagata, Kazufumi;Nakashima-Kamimura, Naomi;Ohta, Shigeo
• 通讯作者: Ohta, Shigeo