Macaques as animal model for gamma-herpesvirus associated lymphomas

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We surveyed for the prevalence of gamma-herpes virus(γHV) or sEBV and 2) found out possible malignant cases caused by theγHVs infection retrospectively in Japanese macaques(Macaca fuscata) and Taiwanese macaques(M. cyclopis). We found that the incidence of the lymphoma was very low compared to the high prevalence of sEBV in those macaque species. Two cases suffering from NK/T-cell lymphoma associated with sEBV in Japanese macaques and Taiwanese macaques were detected. Those results suggest that both two species are suitable for an animal model for human lymphoma associated withγHV.