Development of a musculoskeletal computer model for laboratory mice

我们开发了一个实验室小鼠的肌肉骨骼计算机模型，其遗传背景已经建立。我们利用动作捕捉技术建立了一个全新的鼠标运动功能分析框架和肌肉骨骼计算机模型。为了建立一个可靠的实验室小鼠肌肉骨骼计算机模型，我们设计了一种新的方法，将人类肌肉骨骼模型的信息映射到小鼠骨骼模型上。此外，我们通过使用转基因小鼠的切片数据重建的肌腱组织的三维几何形状来验证和改进模型。

We developed a musculoskeletal computer model for laboratory mice, whose genetic backgrounds have been established. We employed the motion capture technology to establish a totally new framework for mouse motor function analyses with the musculoskeletal computer model. To develop a reliable musculoskeletal computer model for laboratory mice, we devised a new method to map information on a human musculoskeletal model onto a mouse skeletal model. Furthermore, we performed validation and improvement of the model by using 3-dimensional geometries of tendon tissues reconstructed from sliced data of a transgenic mouse.