Relation of apex-to-base dispersion in diastolic lengthening to left ventricular diastolic function evaluated by tissue tracking system

组织追踪系统评估舒张期延长的心尖底离散度与左心室舒张功能的关系

• 批准号: 20500420
• 负责人: MURATA Kazuya
• 金额: $ 3.08万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500420/
• 关键词: 超音波医学; 心不全; 医用システム; 生理学; 解析学; 肥大型心筋症

METHODS : We obtained basal and apical LV short-axis views in 27 patients with non-obstructive HCM and 25 healthy volunteers. Eight equiangular points on the endo-myocardium at end-diastole were placed in each view, and the movements of these points were automatically tracked using a two-dimensional echocardiographic tissue tracking system. Time-LV radial shortening curves were obtained and averaged. The time intervals from the aortic valve closure to the point of the first 40% of peak lengthening (T_<40>) were measured in each view. RESULTS : The time difference in the T_<40> between the apex and base (Δ-T_<40>) in the HCM group was greater than that in the control group. There were good linear correlations between the Δ-T_<40> and the LV early diastolic echo-parameters and the LV mass index. CONCLUSIONS : Our results suggested that apical non-uniformity resulted in loss of active mechanical coordination of apex-to-basal lengthening, which could contribute to global LV diastolic impairment.

方法：我们获得了27例非梗阻性肥厚型心肌病患者和25例健康志愿者的左室短轴基底和心尖切面。在每个视图中放置8个等角点，这些点的运动使用二维超声心动图组织跟踪系统自动跟踪。获得时间-LV径向缩短曲线并取平均值。测量主动脉瓣关闭至峰值延长前40%的时间间隔（T_<40>）。结果：HCM组心尖部与基底部的T_1时间差<40>（Δ-T_1<40>）大于对照组。Δ-T_1<40>与左室舒张早期回声参数及左室质量指数呈良好的线性相关。结论：我们的研究结果表明，心尖部的不均匀性导致心尖部到基底部延长的主动机械协调的丧失，这可能导致整体LV舒张功能受损。

项目成果

今さら聞けない心エコー図100

100张你现在听不到的超声心动图

• 发表时间: 2011
• 作者: Saito M;Okayama H;Yoshii T;Hiasa G;Sumimoto T;Inaba S;Nishimura K;Inoue K;Ogimoto A;Shigematsu Y;Funada JI;Hamada M;Higaki J.;Shigeki Kobayashi;村田和也(執筆者:楠瀬賢也)
• 通讯作者: 村田和也(執筆者:楠瀬賢也)

左室のねじれをどう評価し、どう臨床に役立てるか

如何评估左心室扭转及其临床应用

• 发表时间: 2009
• 期刊: 医学のあゆみ vol 230
• 作者: 田中健雄;村田和也
• 通讯作者: 村田和也

私の考える拡張障害

我对扩张障碍的看法

• 发表时间: 2008
• 期刊: J Cardiol Jpn Ed vol 2
• 作者: 村田和也;木原千景;安藤みゆき;松崎益徳
• 通讯作者: 松崎益徳

Nonuniformity of Left Ventricular Apical-to-Basal Diastolic Lengthening in Patients with Hypertrophic Nonobstructive Cardiomyopathy

肥厚型非梗阻性心肌病患者左心室心尖至基底舒张期延长的不均匀性

• 发表时间: 2008
• 作者: Takeo Tanaka

左室収縮不全心における左室心基部と心尖部での拡張開始時相差と拡張機能の関係 : 超音波組織トラッキング法による検討

左心室收缩功能障碍患者舒张功能与左心室基底部和心尖部舒张起始相位差的关系：超声组织追踪法研究

• 发表时间: 2008
• 作者: 柴田攻;和田靖明;柴田攻;木原千景
• 通讯作者: 木原千景