Evaluation of left ventricular torsion by two dimensional tissue tracking system

二维组织跟踪系统评价左心室扭转

• 批准号: 18500378
• 负责人: MURATA Kazuya
• 金额: $ 2.52万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500378/
• 关键词: Ultrasonics; Heart Failure; Echocardiograoh; Physiology; Cardiology

Background: The Two-Dimensional Tissue Tracking (2DTT) technique can trace regional myocardial tissue using pattern matching method. The 2DTT has a capability to clinically evaluate the left ventricular (LV) torsion in endocardium (Endo) and epicardium (Epi) separately. Our objective was to characterize the response of LV torsion to low-dose dobutamine (Dob)infusion using 2DTT in idiopathic dilated cardiomyopathy (DCM). Methods: Ten patients with DCM were studied. We acquired LV basal and apical short-axis views both at rest and during Dob infusion (5, 10μg/kg/min) using Hitachi EUB-7500 ultrasound machine equipped with 2DTT software. Eight points were manually placed both at Endo and Epi equally in each basal and apical view. The movements of these points were automatically tracked by the system throughout a cardiac cycle. The center of rotation in each frame was determined by customized software, and rotation angle of each point was calculated and averaged. The LV torsion was defined as net-difference between basal and apical rotation angle. LV end-diastolic volume and LV end-systolic volume (ESV)were assessed by the biplane Simpson's equation. Results: Seven of 10 patients showed more than 10% reduction in ESV after 10μg/kg/min Dob infusion(responder). In responders, both apical Endo and Epi rotation increased at 10μg/kg/min Dob infusion (Endo: 1.2±1.1 to 3.6±1.8°, Epi: 0.8±0.7 to 2.3±1.2, p<0.01, respectively), however, basal rotation angles unchanged throughout of study. Consequently, the LV torsion in Endo and Epi increased after Dob infusion (Endo: 3.1±1.7 to 5.7±1.6°, Epi: 2.4±1.0 to 4.6±1.7, p<0.05, respectively).On the other hand, in patients with poor LV response to Dob infusion, basal and apical rotation angles unchanged during Dob infusion. Conclusions: The augmentation of LV rotation was observed especially in apex by inotropic stimulation, which may reflect myocardial contractile reserve in DCM.

背景：二维组织追踪（2DTT）技术可以利用模式匹配的方法追踪局部心肌组织。2DTT能够在临床上分别评价心内膜（Endo）和心外膜（Epi）中的左心室（LV）扭转。我们的目的是使用2DTT描述特发性扩张型心肌病（DCM）患者左室扭转对低剂量多巴酚丁胺（Dob）输注的反应。方法：10例DCM患者。我们使用配有2DTT软件的Hitachi EUB-7500超声机在静息和Dob输注期间（5，10μg/kg/min）采集LV基底和心尖短轴视图。在每个基底和心尖视图中，在Endo和Epi手动放置8个点。这些点的运动由系统在整个心动周期中自动跟踪。通过定制软件确定每帧中的旋转中心，并计算和平均每个点的旋转角度。左室扭转定义为基底和心尖旋转角之间的净差。采用双平面Simpson方程计算左室舒张末期容积和左室收缩末期容积（ESV）。结果：10例患者中有7例在10μg/kg/min Dob输注后ESV下降超过10%（应答者）。在应答者中，在10μg/kg/min Dob输注时，心尖Endo和Epi旋转均增加（Endo：1.2±1.1至3.6±1.8°，Epi：0.8±0.7至2.3±1.2，p<0.01），然而，基底旋转角度在整个研究中保持不变。因此，在输注Dob后，左心室Endo和Epi的扭转增加（Endo：3.1±1.7至5.7±1.6°，Epi：2.4±1.0至4.6±1.7，p<0.05）。结论：收缩力刺激可使左室旋转增加，尤其是心尖部，反映DCM心肌收缩储备功能。

项目成果

Transmural gradient of Left Ventricular Systolic Torsion in Patients with Left Ventricular Hypertrophy

左心室肥厚患者左心室收缩期扭转的透壁梯度

• 发表时间: 2007
• 作者: Hong;J.;Matsumoto;N.;Ouchida;R.;Komune;S.;Hashizume;M;Takeo Tanaka;Takeo Tanaka
• 通讯作者: Takeo Tanaka

Maturational Modulation of Right Ventricular Longitudinal and Radial Strain : Comparison with Left Ventricle using Two Dimensional Tissue Tracking System

右心室纵向和径向应变的成熟调节：使用二维组织跟踪系统与左心室进行比较

• 发表时间: 2007
• 作者: Yasuaki;Wada
• 通讯作者: Wada

心臓再同期療法の左室捻れ運動に及ぼす影響-Two dimensional tissue tracking法による検討-

心脏再同步治疗对左心室扭转运动的影响 - 使用二维组织跟踪方法的研究 -

• 发表时间: 2007
• 作者: Takeo;Tanaka;田中 健雄;村田 和也;Eizo Akagawa;Takeo Tanaka;Eizo Akagawa;Yasuaki Wada;Takeo Tanaka;Takeo Tanaka;Takeo Tanaka;田中 健雄
• 通讯作者: 田中 健雄

Augmentation of left ventricular apical endocardial rotation with inotropic stimulation contributes to increased left ventricular torsion and radial strain in normal subjects - Quantitative assessment utilizing a novel automated tissue tracking technique

• DOI: 10.1253/circj.71.661
• 发表时间: 2007-05-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Akagawa, Eizo;Murata, Kazuya;Matsuzaki, Masunori
• 通讯作者: Matsuzaki, Masunori

肥大型心筋症における左室心内膜側と心外膜側の捻れ運動の検討

肥厚型心肌病左心室心内膜、心外膜两侧扭转运动的检查

• 发表时间: 2007
• 作者: Hong;J.;Matsumoto;N.;Ouchida;R.;Komune;S.;Hashizume;M;田中 健雄
• 通讯作者: 田中 健雄